Mesenchymal Stem Cells Beyond Regenerative Medicine

Frontiers in Cell and Developmental Biology
Riam ShammaaMoutih Rafei

Abstract

Mesenchymal stem cells (MSCs) are competent suitors of cellular therapy due to their therapeutic impact on tissue degeneration and immune-based pathologies. Additionally, their homing and immunomodulatory properties can be exploited in cancer malignancies to transport pharmacological entities, produce anti-neoplastic agents, or induce anti-tumor immunity. Herein, we create a portfolio for MSC properties, showcasing their distinct multiple therapeutic utilities and successes/challenges thereof in both animal studies and clinical trials. We further highlight the promising potential of MSCs not only in cancer management but also in instigating tumor-specific immunity - i.e., cancer vaccination. Finally, we reflect on the possible reasons impeding the clinical advancement of MSC-based cancer vaccines to assist in contriving novel methodologies from which a therapeutic milestone might emanate.

Associated Clinical Trials

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Citations

May 14, 2020·Stem Cell Reviews and Reports·Benjamin Debuc, David M Smadja
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Jing LiuXiaoting Liang
Nov 3, 2020·Biological & Pharmaceutical Bulletin·Yusuke KonoTakuya Fujita
Nov 13, 2020·World Journal of Stem Cells·Perrine BurdeyronClara Steichen
Dec 18, 2020·Frontiers in Cell and Developmental Biology·André CoelhoAna Colette Maurício
Mar 2, 2021·Medicinal Research Reviews·Bruna C GalgaroMárcia R Wink
May 15, 2020·Stem Cell Reviews and Reports·Benjamin Debuc, David M Smadja
Apr 6, 2021·Frontiers in Medicine·Abed El-Hakim El-KadiryRiam Shammaa
Apr 30, 2021·Frontiers in Physiology·Maria Cimini, Raj Kishore
May 8, 2021·World Journal of Stem Cells·Nassem Ahamad, Brij B Singh
May 2, 2021·Clinical and Translational Medicine·Sowmya RameshVrisha Madhuri

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Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT01157650
NCT00420134
NCT00956891
NCT01389661
NCT00366145

Software Mentioned

NeuroNata

Related Concepts

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Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

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