Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro

Experimental and Therapeutic Medicine
Xiaoyi LiuZhigang Yu

Abstract

Breast cancer is the most common malignancy among females throughout the world. Current treatments have unsatisfactory outcomes due to the dispersed nature of certain types of the disease. The development of a more effective therapy for breast cancer has long been one of the most elusive goals of cancer gene therapy. In the present study, human mesenchymal stem cells derived from umbilical cord (hUMSCs) genetically modified with interleukin 18 (IL-18) gene were used to study the effect of hUMSCs/IL-18 on the growth, migration and invasion of MCF-7 and HCC1937 cells in vitro. The hUMSCs could be efficiently modified by lentiviral systems and stably expressed IL-18 protein. hUMSCs/IL-18, but not hUMSCs without the IL-18 gene transduction, significantly suppressed the proliferation, migration and invasion of the MCF-7 and HCC1937 cells. The mechanism of this proliferation suppression may have involved the induction of G1- to S-phase arrest of the breast cancer cells by the hUMSCs/IL-18. In conclusion, hUMSCs/IL-18 can suppress the proliferation, migration and invasion of breast cancer cells in vitro and may provide an approach for a novel antitumor therapy in breast cancer.

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Citations

Sep 16, 2016·Mediators of Inflammation·Drenka TrivanovićAleksandra Jauković
Jan 13, 2018·Frontiers in Immunology·Faroogh MarofiSeyyed Shamsadin Athari
Oct 27, 2018·Journal of Cellular Physiology·Samaneh ShojaeiSamira Mohammadi-Yeganeh
Feb 23, 2019·Microscopy Research and Technique·Xiufeng Li, Zongming Li
Jul 14, 2017·Journal of Cellular Physiology·Rana Moradian TehraniHamed Mirzaei
May 29, 2020·Journal of Drug Targeting·Razieh HeidariMohsen Safaei
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Jul 11, 2021·Cell Biology International·Vijayendran GovindasamySoon-Keng Cheong
Aug 18, 2021·Molecular Therapy. Nucleic Acids·Weiwei ZhuangKeqing Shi

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Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay
PCR
electrophoresis
Assay
light microscopy

Software Mentioned

LT
Prism
[UNK]
ImageJ
Primer Express
GraphPad

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