Mesenchymal Stem Cells for Cardiac Regenerative Therapy: Optimization of Cell Differentiation Strategy

Stem Cells International
Han ShenZhenya Shen

Abstract

With the high mortality rate, coronary heart disease (CHD) has currently become a major life-threatening disease. The main pathological change of myocardial infarction (MI) is the induction of myocardial necrosis in infarction area which finally causes heart failure. Conventional treatments cannot regenerate the functional cell efficiently. Recent researches suggest that mesenchymal stem cells (MSCs) are able to differentiate into multiple lineages, including cardiomyocyte-like cells in vitro and in vivo, and they have been used for the treatment of MI to repair the injured myocardium and improve cardiac function. In this review, we will focus on the recent progress on MSCs derived cardiomyocytes for cardiac regeneration after MI.

References

Mar 13, 1999·The Journal of Clinical Investigation·S MakinoS Ogawa
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Viatchenko-KarpinskiJ Hescheler
Jan 20, 2000·Trends in Cardiovascular Medicine·I S Skerjanc
Jun 10, 2000·British Journal of Haematology·A EricesJ J Minguell
Oct 24, 2000·The Journal of Thoracic and Cardiovascular Surgery·J S WangR C Chiu
Apr 5, 2001·Nature·D OrlicP Anversa
Jun 8, 2001·The Journal of Clinical Investigation·K A JacksonM A Goodell
Aug 30, 2001·The Journal of Biological Chemistry·M JamaliI S Skerjanc
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joanne PaquinJolanta Gutkowska
Jul 13, 2002·The Journal of Pathology·Siân Hughes
Sep 5, 2002·Circulation·Ying Ming ZhangSamuel C Dudley
Nov 1, 2002·Biochemical and Biophysical Research Communications·Koshiro MonzenIssei Komuro
Dec 18, 2002·Cytokine & Growth Factor Reviews·Michael D SchneiderKaren M Lyons
Apr 30, 2003·Arthritis Research & Therapy·Rocky S TuanRichard Tuli
May 7, 2003·Circulation·Dara L KraitchmanJeff W M Bulte
May 7, 2003·Gene Therapy·C JorgensenD Noël
May 17, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Angelo Tocci, Laura Forte
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Sunil RangappaJ Yasha Kresh
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Mar 11, 2004·European Journal of Biochemistry·Robert Saunders, Georgios Scheiner-Bobis
Apr 20, 2004·Experimental Cell Research·Philippe TropelFrançois Berger

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Citations

Feb 24, 2016·Biochemical Pharmacology·Ramin KhanabdaliShiang Y Lim
Jun 3, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y LvL Zhang
Nov 23, 2017·Journal of Translational Medicine·Saioa Gómez-ZoritaMaria P Portillo
May 11, 2018·Journal of Cardiovascular Translational Research·Zi WangYaoliang Tang
Jun 16, 2018·Experimental and Therapeutic Medicine·Yang LvHaiping Wang
May 16, 2019·Stem Cells International·Aofei YangChengjian He
Aug 30, 2017·Molecular Medicine Reports·Runchana MarkmeeChaniporn Puaninta
Jun 21, 2018·Bioengineering·Dominik EggerCornelia Kasper
Mar 7, 2021·Biosensors·Anthony T GiduthuriSoumya K Srivastava

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Methods Mentioned

BETA
genetic modification
percutaneous coronary angioplasty

Software Mentioned

MAGIC
PROTECT
BOOST
CAD
REPAIR

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