Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities

International Journal of Molecular Sciences
Francisco J VizosoRoman Perez-Fernandez

Abstract

Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in tissue homeostasis. In vivo studies have shown MSC paracrine mechanisms displaying proliferative, immunoregulatory, anti-oxidative, or angiogenic activity. In addition, recent studies also demonstrate that depletion and/or dysfunction of MSCs are associated with several systemic diseases, such as lupus, diabetes, psoriasis, and rheumatoid arthritis, as well as with aging and frailty syndrome. In this review, we hypothesize about the role of MSCs as keepers of tissue homeostasis as well as modulators in a variety of inflammatory and degenerative systemic diseases. This scenario opens the possibility for the use of secretome-derived products from MSCs as new therapeutic agents in order to restore tissue homeostasis, instead of the classical paradigm "one disease, one drug".

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Citations

Oct 3, 2019·International Journal of Molecular Sciences·Cliodhna E Murray, Cynthia M Coleman
Jul 24, 2020·Cellular and Molecular Life Sciences : CMLS·Luis A CostaFrancisco J Vizoso
Sep 17, 2020·Stem Cell Research & Therapy·Fatemeh MirershadiRana Keyhanmanesh
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Noemi EiroFrancisco J Vizoso
Sep 19, 2020·Cell & Bioscience·Quan ShiTong Zhang
Oct 30, 2020·Frontiers in Pharmacology·Giulia GolinelliGiulia Grisendi
Apr 4, 2021·International Journal of Molecular Sciences·Silvia Fernández-FrancosFrancisco J Vizoso
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Yanlei YangRobert Chunhua Zhao
Aug 28, 2021·International Journal of Molecular Sciences·Francisco J VizosoNoemi Eiro

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