Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley?

Stem Cells International
Jan HorákMartin Matějovič

Abstract

Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translation of these advances into clinically effective therapies has been disappointing. Given the extreme complexity of sepsis pathogenesis, the paradigm "one disease, one drug" is obviously flawed and combinations of multiple targets that involve early immunomodulation and cellular protection are needed. In this context, the immune-reprogramming properties of cell-based therapy using mesenchymal stem cells (MSC) represent an emerging therapeutic strategy in sepsis and associated organ dysfunction. This article provides an update of the current knowledge regarding MSC in preclinical models of sepsis and sepsis-induced acute kidney injury. Recommendations for further translational research in this field are discussed.

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Citations

Jul 22, 2020·Journal of Cellular Biochemistry·Radbod Darabi, Yong Li
Mar 22, 2019·Cells·Denis N SilachevGennady T Sukhikh
Jul 14, 2020·Frontiers in Veterinary Science·Valeria CaffiClaudio Henríquez
Mar 3, 2020·Frontiers in Immunology·Jan HorakMartin Matejovic
Sep 5, 2018·Molecular and Cellular Biochemistry·Xujing LiangYoupeng Chen
Dec 1, 2020·Frontiers in Pediatrics·Ling Ling LiauJia Xian Law
Aug 24, 2021·Advanced Therapeutics·Stephanie M KronstadtSteven M Jay

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Clinical Trials Mentioned

NCT02883803
NCT02421484

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