Mesenchymal stem cells in the treatment of type 1 diabetes mellitus

Endocrine Pathology
Jana KatuchovaPeter Kruzliak

Abstract

Diabetes mellitus type 1 is a form of diabetes mellitus that results from the autoimmune destruction of insulin-producing beta cells in the pancreas. The current gold standard therapy for pancreas transplantation has limitations because of the long list of waiting patients and the limited supply of donor pancreas. Mesenchymal stem cells (MSCs), a relatively new potential therapy in various fields, have already made their mark in the young field of regenerative medicine. Recent studies have shown that the implantation of MSCs decreases glucose levels through paracrine influences rather than through direct transdifferentiation into insulin-producing cells. Therefore, these cells may use pro-angiogenic and immunomodulatory effects to control diabetes following the cotransplantation with pancreatic islets. In this review, we present and discuss new approaches of using MSCs in the treatment of diabetes mellitus type 1.

References

May 22, 2002·The Journal of Clinical Investigation·Robert E SchwartzCatherine M Verfaillie
Jan 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Przemyslaw BlyszczukAnna M Wobus
Mar 18, 2003·The Journal of Clinical Investigation·Andreea IanusMehboob A Hussain
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Luis A OrtizDonald G Phinney
Aug 6, 2003·Blood·Pieternella S In 't AnkerHumphrey H H Kanhai
Oct 11, 2003·Experimental Hematology·Katarina Le BlancOlle Ringdén
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillermo Muñoz-EliasIra B Black
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Marina MorigiGiuseppe Remuzzi
Sep 21, 2004·World Journal of Gastroenterology : WJG·Li-Bo ChenLian Yang
Feb 16, 2005·Cell Cycle·Marvin C GershengornBruce M Raaka
Jun 1, 2005·Experimental Cell Research·Andrea DickerMikael Rydén
Jul 9, 2005·Nature Biotechnology·Susan Bonner-Weir, Gordon C Weir
Jul 21, 2005·The British Journal of Dermatology·H NakagawaK Akino
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Linheng Li, Ting Xie
Feb 8, 2006·Biochemical and Biophysical Research Communications·Katharina TimperHenryk Zulewski
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Jul 13, 2006·Annals of the New York Academy of Sciences·Julia M Polak, Anne E Bishop
Aug 25, 2006·Nature·Irina KlimanskayaRobert Lanza
Jan 18, 2007·Journal of Cellular Physiology·Yanhua LiXuetao Pei
Mar 17, 2007·Molecular and Cellular Endocrinology·Russell A MortonMarvin C Gershengorn
May 21, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fernando E EzquerPaulette A Conget
Jun 10, 2009·Differentiation; Research in Biological Diversity·Qiu-Ping XieYu-Lian Wu
Jul 2, 2009·Cytotherapy·Jyoti A KodeAnandwardhan A Hardikar
Dec 25, 2009·Blood·Karin TarteUNKNOWN Société Française de Greffe de Moelle et Thérapie Cellulaire
Jun 10, 2010·Current Stem Cell Research & Therapy·Alluru S ReddiNorman Ende
Nov 10, 2010·The Review of Diabetic Studies : RDS·Carmen FotinoAntonello Pileggi

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Citations

Mar 2, 2019·Diabetology & Metabolic Syndrome·Mairim Alexandra SolisLynn L H Huang
Feb 26, 2019·Frontiers in Immunology·Anna GrohováLenka Palová-Jelínková
Feb 18, 2020·Frontiers in Cell and Developmental Biology·Mohamed M Kamal, Dina H Kassem
Feb 15, 2019·International Journal of Molecular Sciences·Mahmoud MonaSeunghee Cha
Sep 14, 2018·Stem Cells International·Ross E B FitzsimmonsCraig A Simmons
Sep 19, 2018·International Journal of Molecular Sciences·Arianna Scuteri, Marianna Monfrini
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Vidul GoenkaRaunak Kumar Das
May 26, 2021·Journal of Biomedical Science·Jana JanockovaJan Rosocha

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