Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis

Current Stem Cell Research & Therapy
Mahsa HajivaliliMehdi Yousefi

Abstract

Amyotrophic lateral sclerosis (ALS is a neurodegenerative disorder which is characterized by motor neuron (MN dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.

Citations

Feb 12, 2020·Journal of Clinical Medicine·Gonzalo José Jimenez-PuertaPatricia Gálvez-Martín
Nov 16, 2017·International Journal of Immunopathology and Pharmacology·Thangavelu Soundara RajanEmanuela Mazzon
Jul 10, 2019·Stem Cells International·Wioletta PawlukowskaBogusław Machaliński
Jun 17, 2021·Phytotherapy Research : PTR·Khadijeh KhezriAbbas Seyed Zakaryaei
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Yuan ZhangRenjie Chai

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