Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation.

PloS One
Marija SajicKenneth J Smith

Abstract

Mesenchymal stem cells have been demonstrated to ameliorate experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, prompting clinical trials in multiple sclerosis which are currently ongoing. An important question is whether this therapeutic effect generalises to other autoimmune neurological diseases. We performed two trials of efficacy of MSCs in experimental autoimmune neuritis (EAN) in Lewis (LEW/Han (M)Hsd) rats, a model of human autoimmune inflammatory neuropathies. No differences between the groups were found in clinical, histological or electrophysiological outcome measures. This was despite the ability of mesenchymal stem cells to inhibit proliferation of CD4+ T-cells in vitro. Therefore the efficacy of MSCs observed in autoimmune CNS demyelination models do not necessarily generalise to the treatment of other forms of neurological autoimmunity.

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Citations

Nov 13, 2013·Nature Reviews. Rheumatology·Alan Tyndall
Apr 2, 2013·Progress in Retinal and Eye Research·John V ForresterMatthew E Wikstrom
Oct 24, 2012·Immunology Letters·Marina M ZafranskayaAlexander S Fedulov
Dec 24, 2015·Frontiers in Physiology·Magdalena M SchimkeGünter Lepperdinger
Jul 29, 2015·Journal français d'ophtalmologie·C RoubeixC Baudouin
Nov 27, 2014·World Journal of Stem Cells·Justin D Glenn, Katharine A Whartenby
Sep 26, 2020·Frontiers in Cell and Developmental Biology·Patricia Kauanna Fonseca DamascenoMilena Botelho Pereira Soares

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