Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties

Cell Death and Differentiation
Meriem Mahrouf-YorgovAnne-Marie Rodriguez

Abstract

Mesenchymal stem cells (MSCs) protect tissues against cell death induced by ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological cues released by the local microenvironment following injury. Recent lines of evidence indicate that MSC can communicate with their microenvironment through bidirectional exchanges of mitochondria. In particular, in vitro and in vivo studies report that MSCs rescue injured cells through delivery of their own mitochondria. However, the role of mitochondria conveyed from somatic cells to MSC remains unknown. By using a co-culture system consisting of MSC and distressed somatic cells such as cardiomyocytes or endothelial cells, we showed that mitochondria from suffering cells acted as danger-signaling organelles that triggered the anti-apoptotic function of MSC. We demonstrated that foreign somatic-derived mitochondria were engulfed and degraded by MSC, leading to induction of the cytoprotective enzyme heme oxygenase-1 (HO-1) and stimulation of mitochondrial biogenesis. As a result, the capacity of MSC to donate their mitochondria to injured cells to combat oxidative stress injury was enhanced. We found that similar mechanisms - activation of autophagy, HO-1 and m...Continue Reading

References

Nov 1, 1995·American Journal of Respiratory Cell and Molecular Biology·L OtterbeinA M Choi
Jan 24, 2004·Apoptosis : an International Journal on Programmed Cell Death·J FangH Maeda
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey L SpeesDarwin J Prockop
Mar 7, 2007·The Journal of Experimental Medicine·Jessy DeshaneAnupam Agarwal
Jul 31, 2008·Developmental Neurobiology·Mandana Amiri, Peter J Hollenbeck
Apr 29, 2009·The Journal of Comparative Neurology·Terry C BurnsWalter C Low
Feb 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Toshinari TsubokawaMasakazu Yamagishi
Feb 20, 2010·The American Journal of Pathology·Kaoru YasudaMichael S Goligorsky
Nov 30, 2010·Cell Death and Differentiation·Y WangY Zhang
Feb 9, 2012·American Journal of Respiratory and Critical Care Medicine·Nancy Chou MacGarveyClaude A Piantadosi
Mar 6, 2012·Cell Stem Cell·Sudhir H RanganathJeffrey M Karp
Mar 7, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min ZhengHun-Taeg Chung
Oct 25, 2012·Current Pharmaceutical Design·Stefan W Ryter, Augustine M K Choi
Nov 24, 2012·Nature Reviews. Molecular Cell Biology·Lorenzo GalluzziGuido Kroemer
Nov 5, 2013·Antioxidants & Redox Signaling·Roberto Motterlini, Roberta Foresti
Apr 15, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sweta RaniThomas Ritter
Jun 13, 2015·Antioxidants & Redox Signaling·Kiichi NakahiraAugustine M K Choi
Aug 11, 2015·Journal of Immunology Research·Pascal RowartFrançois Jouret
Nov 19, 2015·Frontiers in Physiology·Raquel R BartzClaude A Piantadosi

❮ Previous
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Citations

Apr 1, 2018·Journal of Biomedical Science·Swati PaliwalSujata Mohanty
Jul 25, 2018·International Journal of Molecular Sciences·Hung NguyenCesar V Borlongan
Jan 6, 2019·Bioscience Reports·Xing-Liang FanQing-Ling Fu
Jun 22, 2018·Translational Stroke Research·Deepaneeta SarmahPallab Bhattacharya
May 6, 2019·Cellular and Molecular Life Sciences : CMLS·Abderrahim NajiNarufumi Suganuma
Apr 14, 2019·Bioscience Reports·Cheng LiJianxiang Qiu
Jan 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zahra Al Amir DacheAlain R Thierry
Jan 23, 2020·Stem Cells and Development·Lei HuangJohn H Zhang
Jan 30, 2020·International Journal of Molecular Sciences·Abhishek K Singh, Jose A Cancelas
Feb 15, 2019·Stem Cell Research & Therapy·Abderrahim NajiNarufumi Suganuma
Feb 28, 2020·Stem Cells and Cloning : Advances and Applications·Takeo W Tsutsui
Jun 5, 2020·Stem Cells Translational Medicine·Rhian Stavely, Kulmira Nurgali
Oct 12, 2017·The Journal of Trauma and Acute Care Surgery·Ben AntebiLeopoldo C Cancio
Mar 9, 2018·Frontiers in Immunology·Angelo A ManfrediNorma Maugeri
Dec 14, 2018·Acta Neuropathologica Communications·Nabila BoukelmouneCobi J Heijnen
Apr 9, 2019·BioMed Research International·Jian ZhangXiaohu Meng
Jun 25, 2020·International Journal of Molecular Sciences·Jean NakhleMarie-Luce Vignais
Feb 27, 2020·Biomolecules·Simona Neri, Rosa Maria Borzì
Sep 30, 2018·Cellular and Molecular Life Sciences : CMLS·Prajna Paramita NaikSujit Kumar Bhutia
Sep 25, 2019·Cells·Irina V KholodenkoKonstantin N Yarygin
Jun 28, 2020·Translational Stroke Research·Wei ChenAlireza Sarkaki
Oct 3, 2018·Aging and Disease·Fan LiuQin Hu
Apr 5, 2019·Nature Biomedical Engineering·James Q YinJames A Ankrum
Jun 20, 2019·Frontiers in Immunology·Daniel J WeissBernard P Mahon
May 22, 2019·International Journal of Molecular Sciences·Benjamin BochonGrzegorz Wystrychowski

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Methods Mentioned

BETA
GTPase
transmission electron microscopy
flow cytometry
PCR

Software Mentioned

PromoCell
ImageJ
GraphPad Prism
ImageLab

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