Mesenchymal stem cells therapeutic potential alleviate lipopolysaccharide-induced acute lung injury in rat model

Journal of Biochemical and Molecular Toxicology
Maha G SolimanNahla A Hassaan

Abstract

Inhalation of bacterial endotoxin induces an acute inflammation in the lower respiratory tract. The current study examined the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) in lipopolysaccharide (LPS)-induced pulmonary congestion in rats as compared with dexamethasone (Dexa) and sodium bicarbonate (NaHCO3 ). LPS (20 µL of LPS of Escherichia coli in each nostril for two consecutive days) induced lung injury as marked by an elevation of number of inflammatory cells especially neutrophils, increased total protein levels, elevation of lipid peroxidation, and reduction of reduced glutathione in bronchoalveolar lavage along with the reduction of reduced glutathione. These deleterious effects were hampered after treatment with BM-MSCs (1 × 106  cells/rat) once before acute lung injury (ALI) induction with LPS to an even better extent than Dexa (2 mg/kg once, ip) and NaHCO3 (10-15 mL/day for two consecutive days). In summary, BM-MSCs have the ability to suppress the endotoxin-induced systemic inflammatory response and could prove to be a novel approach to therapy for ALI in rats.

References

Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Apr 1, 1987·Annals of Internal Medicine·R G Narins, J J Cohen
Jan 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·C A Feghali, T M Wright
Apr 8, 1999·Intensive Care Medicine·P G MetnitzW Druml
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Mar 30, 2001·Bone Marrow Transplantation·O N Koç, H M Lazarus
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·James G WagnerJack R Harkema
Aug 9, 2003·The New England Journal of Medicine·Martin Kørbling, Zeev Estrov
Sep 4, 2004·Stem Cells and Development·Adel Alhadlaq, Jeremy J Mao
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Apr 4, 2006·Nature Medicine·Yoshinori MiyaharaHidezo Mori
Jun 2, 2007·British Journal of Haematology·James M FoxJim Middleton
Feb 12, 2008·Chest·Massimo Zambon, Jean-Louis Vincent
Jul 31, 2008·American Journal of Respiratory Cell and Molecular Biology·Smita S IyerMauricio Rojas
Oct 22, 2008·Transplantation Proceedings·J H SungS-J Kim
Mar 12, 2009·Cancer Research·Ian F RobeyRobert J Gillies
Aug 10, 2010·The European Respiratory Journal·T Maron-GutierrezM M Morales
Dec 1, 2010·Methods in Molecular Biology·Joseph D TarioPaul K Wallace
Jul 28, 2012·International Immunopharmacology·Xiaojun ChenZhiliang Sun

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