Mesenchymal stem cells with rhBMP-2 inhibits the growth of canine osteosarcoma cells.

BMC Veterinary Research
Rose Eli Grassi RiciDurvanei Augusto Maria

Abstract

The bone morphogenetic proteins (BMPs) belong to a unique group of proteins that includes the growth factor TGF-β. BMPs play important roles in cell differentiation, cell proliferation, and inhibition of cell growth. They also participate in the maturation of several cell types, depending on the microenvironment and interactions with other regulatory factors. Depending on their concentration gradient, the BMPs can attract various types of cells and act as chemotactic, mitogenic, or differentiation agents. BMPs can interfere with cell proliferation and the formation of cartilage and bone. In addition, BMPs can induce the differentiation of mesenchymal progenitor cells into various cell types, including chondroblasts and osteoblasts. The aim of this study was to analyze the effects of treatment with rhBMP-2 on the proliferation of canine mesenchymal stem cells (cMSCs) and the tumor suppression properties of rhBMP-2 in canine osteocarcoma (OST) cells. Osteosarcoma cell lines were isolated from biopsies and excisions of animals with osteosarcoma and were characterized by the Laboratory of Biochemistry and Biophysics, Butantan Institute. The mesenchymal stem cells were derived from the bone marrow of canine fetuses (cMSCs) and belon...Continue Reading

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Citations

Jun 21, 2014·Current Reviews in Musculoskeletal Medicine·Brett WalkerKris Radcliff
Aug 15, 2015·Spine·Branko SkovrljSamuel K Cho
Feb 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying ZhengXin Chang
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Feb 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Haijun TianSamuel S Murray
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Jun 14, 2021·Research in Veterinary Science·Ana CarolinaSilveira RabeloMaria Angélica Miglino

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Methods Mentioned

BETA
biopsies
flow cytometry

Software Mentioned

GraphPad Prism

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