Mesenchymal stem cells

Thorax
Sara Rankin

Abstract

Mesenchymal Stem cells (MSCs) are stromal cells that can be readily harvested from adult bone marrow and adipose tissue, but also umbilical cords. With respect to respiratory disease, the therapeutic potential of these cells lies in their paracrine effects which underlie their ability to enhance tissue regeneration and modulate immune responses. MSCs have been shown to be effective in a range of murine models of respiratory disease, and there are currently five clinical trials involving the administration of MSCs for respiratory diseases, including COPD and emphysema. This paper summarises the features of MSCs.

Citations

Jan 30, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Danielle Niver
Feb 11, 2014·Clinics in Chest Medicine·Clare L Ross, Trevor T Hansel
Apr 23, 2013·Current Opinion in Pharmacology·Anta Ngkelo, Ian M Adcock
Mar 21, 2018·Biomedical Reports·Katerina M AntoniouNikos Tzanakis
Jul 13, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E RatemiR Halwani

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