Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling

Cancer Letters
Amélie VézinaBorhane Annabi

Abstract

The primary cilium is a cell surface-anchored sensory organelle which expression is lost in hypoxic cancer cells and during mesenchymal stromal cells (MSC) adaptation to low oxygen levels. Since pro-inflammatory cues are among the early events which promote tumor angiogenesis, we tested the inflammatory cytokine tumor necrosis factor (TNF)-α and found that it triggered a dose-dependent loss of the primary cilia in MSC. This loss was independent of IFT88 expression, was abrogated by progranulin, an antagonist of the TNF receptor and required the NF-κB signaling intermediates IκB kinase α, β, and γ, as well as NF-κB p65. These findings strengthen the concept that the primary cilium may serve as a biomarker reflecting the tumor-supporting potential of MSC and their capacity to adapt to hypoxic and pro-inflammatory cues.

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Citations

Apr 23, 2014·Immunology and Cell Biology·Nima EtemadiUeli Nachbur
Aug 20, 2014·Nature Communications·Thibaut EguetherAnne-Marie Tassin
Aug 10, 2016·Annals of the New York Academy of Sciences·Jianlu WeiChuanju Liu
Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ming WuChanglin Mei
Sep 21, 2017·Journal of Neuroinflammation·Hyunjung BaekDong Woon Kim
Sep 27, 2015·Protein & Cell·Betty C WangJinlong Jian
Feb 13, 2014·Immunology and Cell Biology·Sardar M Z UddinChuan-ju Liu
Feb 6, 2020·Science Signaling·Jens MeschedeKonstanze F Winklhofer
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Mayu HosioEsko Kankuri
Jun 30, 2021·The Journal of Clinical Investigation·Wenyu FuChuan-Ju Liu

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