Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?

American Journal of Physiology. Gastrointestinal and Liver Physiology
Andrew Owen, Philip N Newsome

Abstract

End-stage liver disease is responsible for 30,000 deaths per year in the United States alone, and it is continuing to increase every year. With liver transplantation the only curative treatment currently available, new therapies are in great demand. Mesenchymal stem cells (MSC) offer an opportunity to both treat liver inflammatory damage, as well as reverse some of the changes that occur following chronic liver injury. With the ability to regulate both the innate and adaptive immune system, as well as both inhibit and promote apoptosis of effector inflammatory cells, there are numerous therapeutic opportunities for MSC in acute and chronic liver disease. This article critically appraises the potential therapeutic roles of MSC in liver disease, as well as the barriers to their adoption into clinical practice.

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Citations

Dec 21, 2017·Inflammation and Regeneration·Atsunori TsuchiyaShuji Terai
Mar 6, 2019·Journal of Tissue Engineering·Iva BurovaRebecca J Shipley
May 17, 2019·Expert Review of Gastroenterology & Hepatology·Alexander BoydWei-Yu Lu
Mar 23, 2018·Stem Cell Research & Therapy·Lu ZhaoLanjuan Li
Apr 27, 2016·Expert Opinion on Biological Therapy·Ryuichi Okamoto, Mamoru Watanabe
Jul 9, 2020·Frontiers in Immunology·Andrew Owen, Philip N Newsome
Jan 6, 2016·Biomedicines·Clara NicolasScott L Nyberg

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Methods Mentioned

BETA
flow cytometry

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