Mesenchymal Stromal Cells for Graft Versus Host Disease: Mechanism-Based Biomarkers.

Frontiers in Immunology
Tik Shing CheungAntonio Galleu

Abstract

The immunosuppressive activity of mesenchymal stromal cells (MSCs) in graft versus host disease (GvHD) is well-documented, but their therapeutic benefit is rather unpredictable. Prospective randomized clinical trials remain the only means to address MSC clinical efficacy. However, the imperfect understanding of MSC biological mechanisms has undermined patients' stratification and the successful design of clinical studies. Furthermore, although MSC efficacy seems to be dependent on patient-associated factors, the role of patients' signature to predict and/or monitor clinical outcomes remains poorly elucidated. The analysis of GvHD patient serum has identified a set of molecules that are associated with high mortality. However, despite their importance in defining GvHD severity, their role in predicting or monitoring response to MSCs has not been confirmed. A new perspective on the use of MSCs for GvHD has been prompted by the recent findings that MSCs are actively induced to undergo apoptosis by recipient cytotoxic cells and that this process is essential to initiate MSC-induced immunosuppression. This discovery has not only reconciled the conundrum between MSC efficacy and their lack of engraftment, but also highlighted the det...Continue Reading

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Citations

Nov 27, 2020·Frontiers in Cell and Developmental Biology·Riccardo BazzoniMauro Krampera
Feb 13, 2021·International Journal of Molecular Sciences·Shoichiro TaniHironori Hojo
Mar 23, 2021·Acta Biomaterialia·Sheng Yin, Yi Cao
Jun 3, 2021·International Journal of Molecular Sciences·Robert Maximilian RuschShigeto Shimmura
Oct 9, 2021·Cell Stem Cell·Mauro Krampera, Katarina Le Blanc

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Clinical Trials Mentioned

NCT00562497
NCT00366145

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Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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