Mesenchymal Stromal Cells in Pediatric Hematopoietic Cell Transplantation a Review and a Pilot Study in Children Treated With Decidua Stromal Cells for Acute Graft-versus-Host Disease.

Frontiers in Immunology
Olle RingdénBehnam Sadeghi

Abstract

Mesenchymal stromal cells (MSCs) are rare precursors in all organs of the body. MSCs have profound anti-inflammatory effects and reduce alloreactivity in vitro and in vivo. In pediatric allogeneic hematopoietic cell transplantation (HCT), MSCs have mainly been used to treat acute graft-versus-host disease (GVHD). MSCs are commercially available for this indication in Canada, Japan, and New Zeeland. More rare indications for MSCs in pediatric patients include graft failure and chronic GVHD. MSCs from bone marrow, adipose tissue, umbilical cord, Wharton's jelly, placenta tissue, and decidua have been used, but the optimal clinical stromal cell source has not been compared in clinical trials. More experimental clinical indications using MSCs, such as sepsis, acute respiratory distress syndrome, hemorrhages, pneumo-mediastinum, and neuroinflammation have primarily been explored in animal models or adult HCT patients. MSCs have almost no if any side-effects. In this pilot study we report the outcome of six children treated with decidua stromal cells (DSCs) for steroid refractory acute GVHD. At 6 months, complete response was seen in four patients and partial response in two patients. One child with high-risk ALL died from relapse an...Continue Reading

References

Dec 1, 1985·Immunological Reviews·R Storb, E D Thomas
Oct 3, 1981·Lancet·J R Hobbs
Oct 1, 1984·Transplantation·C G Groth, O Ringdén
Apr 2, 1999·Science·M F PittengerD R Marshak
Feb 2, 2002·Experimental Hematology·Amelia BartholomewRonald Hoffman
Oct 11, 2003·Experimental Hematology·Katarina Le BlancOlle Ringdén
Oct 21, 2004·Blood·Sudeepta Aggarwal, Mark F Pittenger
Apr 23, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katarina Le Blanc, Olle Ringdén
Apr 23, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hillard M LazarusAndrea Bacigalupo
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
May 30, 2006·Transplantation·Olle RingdénKatarina Le Blanc
Aug 1, 2007·Blood·Alma J Nauta, Willem E Fibbe
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon JonesFrancesco Dazzi
May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
May 14, 2009·Transplantation·Zohair SelmaniFrédéric Deschaseaux
Jun 6, 2009·Nature Reviews. Immunology·Clotilde ThéryElodie Segura

❮ Previous
Next ❯

Citations

May 1, 2021·Reproductive Biology·Prasad Pethe, Vaijayanti Kale

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
PCR
biopsy

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.