Mesenteric Adipocyte Dysfunction in Crohn's Disease is Associated with Hypoxia

Inflammatory Bowel Diseases
Lugen ZuoJieshou Li

Abstract

Abnormalities in mesenteric adipose tissue (MAT) have long been recognized; however, the functional changes in the mesenteric adipocytes as well as the underlying mechanisms are not entirely clear. The aim of this study was to analyze the function and morphology of the MAT in patients with Crohn's disease (CD) and the underlying mechanism. The MAT specimens were obtained from areas adjacent to the intestinal wall in patients with CD (n = 33) and without CD (control, n = 23) who underwent intestinal resection. For patients with CD, paired samples were obtained from the macroscopically hypertrophic mesenteric adipose tissue (htMAT), adjacent to the involved ileum, and the macroscopically normal mesenteric adipose tissue (nMAT), contiguous with the healthy segment of the ileum. Morphological and molecular techniques were used to detect the characteristics of the MAT of CD and compare them with the characteristics of the control tissues. Hypoxia was confirmed by a high expression of hypoxia-inducible factor 1α. The function and morphology of the nMAT in patients with CD were similar to those of the control tissues. htMAT of CD was dysfunctional based on the evidence that htMAT exhibited decreased lipid store, fatty acid synthase, a...Continue Reading

References

Sep 1, 1992·The British Journal of Surgery·A L SheehanN A Shepherd
Jun 26, 1999·Gastroenterology·P DesreumauxJ F Colombel
Mar 10, 2000·Cytokine & Growth Factor Reviews·J L Wrana, L Attisano
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Kirsi A VirtanenPirjo Nuutila
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Laurence KatznelsonAnne Klibanski
Jul 12, 2005·Pflügers Archiv : European journal of physiology·Eoin P Cummins, Cormac T Taylor
Sep 8, 2006·Gut·Laurent Peyrin-BirouletPierre Desreumaux
Dec 7, 2007·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Jan 22, 2008·Biochemical and Biophysical Research Communications·Bohan WangPaul Trayhurn
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Namasivayam AmbalavananYiu-Fai Chen
Jul 25, 2008·The Biochemical Journal·Niall Steven Kenneth, Sonia Rocha
Mar 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Raanan Shamir
Jul 14, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Benjamin BertinLaurent Dubuquoy
Aug 5, 2010·Inflammatory Bowel Diseases·Isabelle OlivierHélène Eutamène
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Oct 14, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael SpencerPhilip A Kern
Dec 4, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lotta K StenmanRiitta Korpela
Apr 17, 2013·International Journal of Molecular Medicine·Wenpeng DongWeida Zhang
Nov 10, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yun FengJieshou Li
Apr 29, 2014·Molecular Cell·Jason W Upton, Francis Ka-Ming Chan
Sep 24, 2014·Inflammatory Bowel Diseases·Pedro GonçalvesFátima Martel
Oct 14, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Yi LiJieshou Li
Oct 24, 2014·Thrombosis and Haemostasis·F MolicaS Steffens

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Citations

May 31, 2018·Current Opinion in Gastroenterology·Carl WeidingerBritta Siegmund
Jun 28, 2018·Journal of Crohn's & Colitis·Weisong ShenWeiming Zhu
Oct 9, 2018·Inflammatory Bowel Diseases·Weisong ShenWeiming Zhu
May 11, 2017·Journal of Clinical Gastroenterology·Burton I KorelitzJeffrey Aronoff
Oct 2, 2021·Clinical and Translational Gastroenterology·Yipeng ZhuWeiming Zhu

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