Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis

Shock
E M CameronF W Sellke

Abstract

This study was performed to assess the effects of subacute sepsis in rats on the in vitro reactivity of arterioles (internal diameter, 100-150 microm) to alpha1- and alpha2-adrenergic stimulation and to angiotensin II. Male Sprague-Dawley rats were rendered septic by intraperitoneal implantation of a gelatin capsule containing sterile rat feces and 1 x 10(6) viable colony forming units of Escherichia coli. Control rats underwent sham laparotomy and implantation of a gelatin capsule containing only sterile feces. In vitro reactivity of arterioles from mesentery and skeletal muscle were studied 48 h later in a pressurized (50 mmHg) no flow state using videomicroscopy. Subacute sepsis decreased the contractile response of nonprecontracted microvessels from both anatomical sites to phenylephrine (both p < .01 versus control) and blunted the relaxation response to staurosporine (both p < .01), an inhibitor of protein kinase C. The small contraction to angiotensin II of mesenteric vessels was inhibited by sepsis (p < .05) but was unaltered in the skeletal muscle microcirculation. In the precontracted mesenteric microvessels from septic rats, endothelium-dependent relaxation to clonidine and to adenosine 5'-diphosphate were decreased ...Continue Reading

Citations

Oct 27, 2009·Journal of Hepatology·Marco DomenicaliMauro Bernardi
Feb 24, 2000·The Journal of Pathology·H A LehrC J Kirkpatrick
Jul 26, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Michael LauterbachOliver Kempski
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert H RosaLih Kuo
May 26, 2001·The Journal of Biological Chemistry·C ZhangC R White
Apr 26, 2002·Anesthesia and Analgesia·Steven Y WangScott Segal
Feb 22, 2001·Journal of Applied Physiology·J ArmourJ X Wilson

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