Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice

Scientific Reports
A-Ram KimWahn Soo Choi

Abstract

Food allergy is a hypersensitive immune reaction to food proteins. We have previously demonstrated the presence of IL-10-producing CD5(+) B cells and suggested their potential role in regulating cow's milk casein allergy in humans and IgE-mediated anaphylaxis in mice. In this study, we determined whether IL-10-producing CD5(+) regulatory B cells control casein-induced food allergic responses in mice and, if so, the underlying mechanisms. The induction of oral tolerance (OT) by casein suppressed casein-induced allergic responses including the decrease of body temperature, symptom score, diarrhea, recruitment of mast cells and eosinophils into jejunum, and other biological parameters in mice. Notably, the population of IL-10-producing CD5(+) B cells was increased in mesenteric lymph node (MLN), but not in spleen or peritoneal cavity (PeC) in OT mice. The adoptive transfer of CD5(+) B cells from MLN, but not those from spleen and PeC, suppressed the casein-induced allergic responses in an allergen-specific and IL-10-dependent manner. The inhibitory effect of IL-10-producing CD5(+) B cells on casein-induced allergic response was dependent on Foxp3(+) regulatory T cells. Taken together, mesenteric IL-10-producing regulatory B cells ...Continue Reading

References

Feb 9, 1999·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Feb 13, 2001·Scandinavian Journal of Immunology·E GärdbyN Y Lycke
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·X ZhangH L Weiner
Mar 29, 2002·European Journal of Immunology·Thomas W SpahnTorsten Kucharzik
Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
May 8, 2004·The Journal of Allergy and Clinical Immunology·Hugh A Sampson
May 8, 2004·The Journal of Allergy and Clinical Immunology·Christophe P FrossardPhilippe A Eigenmann
Jun 16, 2004·The Journal of Experimental Medicine·Malin R KarlssonPer Brandtzaeg
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manuel Garcia-Careaga, John A Kerner
Mar 15, 2006·The Journal of Experimental Medicine·Andrew J Macpherson, Karen Smith
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F van WijkL M J Knippels
Jun 9, 2007·The American Journal of Pathology·Rei WatanabeKunihiko Tamaki
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohit KashyapJohn J Ryan
Jul 25, 2008·Nature·Stephen J GalliAdrian M Piliponsky
Sep 2, 2008·Immunological Reviews·Jean-David BouazizThomas F Tedder
Oct 7, 2008·Trends in Immunology·Noriko M Tsuji, Akemi Kosaka
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Wayne G ShrefflerHugh A Sampson
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrike SchulmeisterSusanne Spitzauer
Jul 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BoudousquiéF Spertini
Nov 18, 2009·Pediatrics·Amy M Branum, Susan L Lukacs
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder
Mar 23, 2010·The Journal of Allergy and Clinical Immunology·Sylvie AmuPadraic G Fallon
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rei WatanabeManabu Fujimoto
Jun 15, 2010·The Journal of Allergy and Clinical Immunology·Yitzhak KatzMoshe Leshno
Jul 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi MatsushitaThomas F Tedder
Feb 1, 2011·The Journal of Allergy and Clinical Immunology·Anna Nowak-Węgrzyn, Hugh A Sampson
Feb 2, 2011·The American Journal of Pathology·Koichi YanabaShinichi Sato
Mar 3, 2011·The Journal of Clinical Investigation·Julie Wang, Hugh A Sampson
Jul 8, 2011·The British Journal of Nutrition·Bastiaan SchoutenLinette E M Willemsen
Jul 9, 2011·Allergy, Asthma & Immunology Research·Geunwoong Noh, Jae Ho Lee
Sep 22, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Betty C A M van EschJohan Garssen
Dec 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Damian MasedaThomas F Tedder
Jan 4, 2012·Clinical and Molecular Allergy : CMA·Komei ItoMagnus P Borres
Feb 11, 2012·The American Journal of Pathology·Richard AhrensSimon P Hogan
Jun 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D KrishnamurthyE Jensen-Jarolim
Jan 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mayuka HorikawaThomas F Tedder

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Citations

Mar 5, 2017·Transplant Immunology·C M Wortel, S Heidt
Jan 20, 2017·Allergy, Asthma & Immunology Research·Marcin WawrzyniakMübeccel Akdis
Aug 24, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N WangS P Hogan
Jul 18, 2018·Nutrients·Mensiena B G KiewietPaul de Vos
Oct 21, 2019·International Immunology·Yoshihiro BabaYasuaki Kotetsu
Aug 14, 2020·F1000Research·Sunil Tomar, Simon P Hogan
Jan 9, 2019·Frontiers in Immunology·Pattraporn SatitsuksanoaMübeccel Akdis
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ntshepisa LebetwaShigeru Katayama
Jun 27, 2019·Nutrients·Enza D'AuriaGianVincenzo Zuccotti
Jul 30, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Joseph BeckettSushma Shankar
Dec 22, 2020·Immunological Reviews·Siyuan MaMübeccel Akdis
Dec 5, 2020·Allergy·Pattraporn SatitsuksanoaWillem van de Veen
Oct 28, 2020·Mucosal Immunology·Evelyn CampbellCathryn R Nagler
Apr 18, 2021·Immunology and Allergy Clinics of North America·James Walter KrempskiKari Nadeau
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena
Jun 3, 2021·Nutrients·Domenico GarganoPaola Iovino
Mar 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dajeong LeeWahn Soo Choi
Aug 7, 2021·Current Opinion in Pediatrics·Chioma Udemgba, Adora Lin

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Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

FlowJo
SigmaStat

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