PMID: 9174384May 1, 1997Paper

Mesenteric inflammatory veno-occlusive disease (MIVOD): an emerging and unsuspected cause of digestive tract ischemia

VASA. Zeitschrift für Gefässkrankheiten
J T Lie

Abstract

Mesenteric inflammatory veno-occlusive disease (MIVOD) is a new clinicopathological entity and an unsuspected cause of digestive tract ischemia in the 17 patients reviewed in this article. Of this series, MIVOD occurred twice as often in men as in women, and the age of affected patients ranged from 24 to 78 years. Unexplained ischemic bowel disease was the most common clinical presentation of MIVOD. All patients required surgical exploration and underwent resection of ischemic or gangrenous bowel. None of the patients had a known underlying systemic vasculitis, connective tissue disease, inflammatory bowel disease, infection, drug allergy, or ingestion of food contaminants or toxins. In general, a correct diagnosis of MIVOD is possible in virtually all cases only after careful histological examination of the resected specimens because the endoscopic biopsy findings may be inconclusive. The inflammatory infiltrate of active MIVOD may be lymphocytic, necrotizing, granulomatous, or mixed, and thrombosis is almost invariably also present. The late changes of MIVOD, concentric or eccentric myointimal hyperplasia and occlusive phlebosclerosis, represent organized thrombi. MIVOD probably occurs more commonly than is generally recogniz...Continue Reading

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