Mesenteric lymph nodes at the center of immune anatomy

The Journal of Experimental Medicine
Andrew J Macpherson, Karen Smith

Abstract

The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system.

References

Jan 1, 1981·International Archives of Allergy and Applied Immunology·R G Titus, J M Chiller
Mar 1, 1995·International Immunology·P GarsideA M Mowat
Mar 29, 2002·European Journal of Immunology·Thomas W SpahnTorsten Kucharzik
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M SmithPaul Garside
May 6, 2003·European Journal of Immunology·Désirée KunkelAlexander Scheffold
Mar 15, 2006·The Journal of Experimental Medicine·Tim WorbsOliver Pabst

❮ Previous
Next ❯

Citations

Apr 9, 2008·Inflammatory Bowel Diseases·Bertus EksteenDavid H Adams
Sep 3, 2010·Inflammatory Bowel Diseases·Koichi TakebayashiMatthew B Grisham
Apr 11, 2012·Inflammatory Bowel Diseases·Iurii KobozievMatthew B Grisham
Jul 31, 2013·Journal of Autoimmunity·Palak J Trivedi, David H Adams
Oct 1, 2008·Nature Reviews. Immunology·Tobias JuntBurkhard Ludewig
Nov 14, 2007·Immunology and Cell Biology·Marie LewisStephen Cose
Apr 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takashi ObataHiroshi Kiyono
May 23, 2007·The Journal of Experimental Medicine·Guangyu AnLijun Xia
Oct 24, 2012·Infection and Immunity·Sara E ThorslundMaria Fällman
Jun 3, 2010·Infection and Immunity·Andrea EcheverryBecky Adkins
Nov 28, 2007·Annual Review of Pathology·Jonathan Braun, Bo Wei
Sep 9, 2008·World Journal of Gastroenterology : WJG·Jan Hendrik Niess
Aug 3, 2011·Clinical & Developmental Immunology·Manuel OliveiraJalil Benyacoub
Oct 22, 2013·Applied and Environmental Microbiology·Evelyne MannStephan Schmitz-Esser
Dec 24, 2015·Frontiers in Microbiology·Evelyne MannStephan Schmitz-Esser
Oct 17, 2015·Nature Reviews. Drug Discovery·Natalie L TrevaskisChristopher J H Porter
Dec 15, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Flavia M Souza-SmithJerome W Breslin
Oct 27, 2010·Annals of the New York Academy of Sciences·Iurii KobozievMatthew B Grisham
Apr 15, 2010·Annals of the New York Academy of Sciences·René WismarHelle Nygaard Laerke
Jun 20, 2014·Immunological Reviews·Valérie Abadie, Bana Jabri
Apr 18, 2014·Journal of Applied Microbiology·T S KemgangR Kapila
Jun 30, 2009·Human Immunology·Yaron Ilan
Nov 14, 2015·Science·Ilaria SpadoniMaria Rescigno
Jun 9, 2015·Toxicology Letters·Marina NinkovMilena Kataranovski

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.