Mesenteric vascular reactivity to histamine receptor agonists and antagonists

Digestive Diseases and Sciences
K M WalusE D Jacobson

Abstract

Response patterns of intestinal blood flow, oxygen extraction and consumption, blood flow distribution, and motility were assessed during intraarterial infusions of histamine, histamine after H1 or H2 blockade, dimaprit or dimaprit after H2 blockade. Histamine produced an initial peak response of blood flow with a slow decrease thereafter. Oxygen extraction was evenly depressed throughout the infusion, and oxygen consumption increased at the beginning. All initial responses were blocked by tripelennamine. Ranitidine, a new H2 antagonist, accelerated the decay of all responses. Dimaprit produced effects identical to those of histamine after tripelennamine. Distribution of blood flow was unchanged at the beginning of histamine infusion, but subsequently showed a shift to muscularis which was blocked by tripelennamine. Histamine usually stimulated intestinal contractions and this effect was abolished by tripelennamine. Thus, H1 stimulation, besides producing an initial vasodilation, increases oxygen uptake and redistributes flow to the muscularis.

References

Aug 1, 1979·The Journal of Surgical Research·T A MillerE D Jacobson
Sep 1, 1977·British Journal of Pharmacology·S B FlynnD A Owen
Oct 1, 1975·British Journal of Pharmacology·S B Flynn, D A Owen
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Apr 21, 1972·Nature·J W BlackE M Parsons
Apr 1, 1980·Agents and Actions·M J Daly, R Stables

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Citations

Oct 1, 1985·Digestive Diseases and Sciences·B I Hirschowitz
Aug 1, 1983·The Journal of Pediatrics·R F LemanskeD D Metcalfe

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