Mesial temporal lobe and memory function in autism spectrum disorder: an exploration of volumetric findings

Journal of Clinical and Experimental Neuropsychology
Haley G TrontelJanet E Lainhart

Abstract

Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function int...Continue Reading

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Citations

Jan 20, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Allison Jack, Kevin A Pelphrey
Oct 27, 2017·Journal of Clinical and Experimental Neuropsychology·Sanam J LalaniJanet E Lainhart
Jul 11, 2018·Psychonomic Bulletin & Review·Rose A Cooper, Jon S Simons
Jun 26, 2020·Frontiers in Human Neuroscience·R McKell CarterGabriel S Dichter
Sep 19, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ziarih HawiMark A Bellgrove
May 7, 2021·Neuropsychology Review·Jason W GriffinBrandon E Gavett

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Methods Mentioned

BETA
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Software Mentioned

FreeSurfer

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