Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
J F SumowskiM Filippi

Abstract

Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages. Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier (<10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients. Neuroanatomical correlates of memory deficits differ across disease stages.

References

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Citations

Mar 22, 2019·Biomedicines·Miguel Ángel Macías Islas, Ethel Ciampi
Apr 22, 2018·Current Treatment Options in Neurology·Tim SinneckerRegina Schlaeger
Aug 31, 2018·Nature Reviews. Neuroscience·Massimiliano Di FilippoPaolo Calabresi
Feb 9, 2021·Frontiers in Neurology·Alfonso Delgado-ÁlvarezJorge Matias-Guiu
Apr 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Virginia Meca-LallanaFrancisco Pérez-Miralles
May 6, 2021·Annals of Clinical and Translational Neurology·James F SumowskiAndrew W Varga

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Software Mentioned

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