Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal autoantibodies

Epilepsia
Adaucto W Nóbrega-JrKatia Lin

Abstract

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is characterized by its well-defined clinical profile. Limbic encephalitis is increasingly recognized as a possible etiology of adult-onset MTLE-HS, and neuronal autoantibodies have been detected in patients even without previous signs of encephalitis. The aim of this study is to analyze the frequency of specific autoantibodies in patients with MTLE-HS. A case-control study was carried out with 100 patients with MTLE-HS and 50 healthy controls. Sera samples from subjects were tested by indirect immunofluorescence assay for detection of anti-N-methyl-d-aspartate receptor (NMDA-R), anti-contactin-associated protein-like 2 (CASPR2), anti-leucine-rich glioma inactivated 1 (LGI1), anti-gamma aminobutyric acid B receptor (GABA-B-R), anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 1 and 2 receptors (AMPA-1-R and AMPA-2-R), and enzyme-linked immunosorbent assay for detection of anti-glutamic acid decarboxylase 65 (GAD65). Mean age of patients and controls was 41.2 vs 42 years, and 55% vs 56% were female. Mean duration of epilepsy was 27.2 years. No neuronal autoantibodies were found in either group, except for anti-GAD65 in 3 patients and 2 controls. This ...Continue Reading

References

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Citations

Feb 5, 2019·The Journal of Clinical Investigation·Christian GeisJosep Dalmau
Nov 23, 2020·Brain : a Journal of Neurology·Claude SteriadeRoland D Thijs
Feb 9, 2021·Frontiers in Neurology·Gabriel de Albuquerque VasconcelosPedro Braga-Neto
Jul 21, 2021·Seizure : the Journal of the British Epilepsy Association·Lu ChenQian Wu
Jun 9, 2020·Seizure : the Journal of the British Epilepsy Association·Etsegenet TizazuEric Lancaster
Jul 22, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Fatme Seval IsmailUwe Schlegel
Sep 14, 2021·JAMA Neurology·Claude SteriadeJacqueline French
Aug 21, 2020·Seizure : the Journal of the British Epilepsy Association·Mercè FalipMar Carreño
Jan 8, 2022·The Journal of Applied Laboratory Medicine·Julien HébertDavid F Tang-Wai

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