Mesityl phenanthroline-modified 2'-deoxyuridine for heteroleptic complexes in metal ion-mediated assembly of DNA

Dalton Transactions : an International Journal of Inorganic Chemistry
Philipp Ensslen, Hans-Achim Wagenknecht

Abstract

The synthesis of a new DNA building block that bears the metal ion ligand 2,9-bis-mesityl-3-ethynyl-phenanthroline attached to the 5-position of 2'-deoxyuridine is presented. In the presence of Zn(2+), Cu(2+), Fe(2+) and Ni(2+) the complex formation of an accordingly modified DNA double strand with a second DNA duplex bearing the 2,2':6',2''-terpyridine ligand was studied by optical spectroscopy. The selective formation of heteroleptic assemblies between the two different DNA pieces was evidenced by denaturing polyacrylamide gel electrophoresis.

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Citations

Sep 30, 2015·Organic & Biomolecular Chemistry·Daniel G SingletonEugen Stulz
Sep 24, 2015·Chemical Communications : Chem Comm·Michael Schmittel

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