meso-Dihydroguaiaretic acid attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma

International Immunopharmacology
Ji-Won SongHwa-Young Son

Abstract

meso-Dihydroguaiaretic acid (MDGA), which is a dibenzylbutane lignin isolated from the ethyl acetate fraction of Saururus chinensis, has various biological activities, including anti-oxidative, anti-inflammatory, anti-bacterial, and neuroprotective effects. However, no report has examined the potential anti-asthmatic activity of MDGA. In this study, we evaluated the protective effects of MDGA on asthmatic responses, particularly airway inflammation and mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma. Intragastric administration of MDGA significantly lowered the productions of interleukin (IL)-4, IL-5, IL-13, tumor necrosis-α (TNF-α), eotaxin, monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), and immunoglobulin (Ig)E in bronchoalveolar lavage fluid (BALF), plasma, or lung tissues. Histological studies showed that MDGA inhibited OVA-induced inflammatory cell infiltration and mucus production in the respiratory tract. Moreover, MDGA markedly attenuated the OVA-induced activations of nuclear factor kappa B (NF-κB), extracellular-signal-regulated kinases 1/2 (ERK1/2), and p38 mitogen-activated protein kinase (p38 MAPK). Together, these results suggest that MDGA effectiv...Continue Reading

References

Oct 1, 1996·General Pharmacology·A D HughesC Demoliou-Mason
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
Mar 22, 2002·Nature Reviews. Immunology·N W Lukacs
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Joerg Mattes, Paul S Foster
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Richard LeighMark D Inman
Feb 7, 2004·Planta medica·Choong Je MaYoung Choong Kim
Oct 16, 2004·Bioorganic & Medicinal Chemistry Letters·Woo Song LeeTae-Sook Jeong
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Rodolfo M Pascual, Stephen P Peters
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
May 17, 2007·Current Allergy and Asthma Reports·Elizabeth A JacobsenJames J Lee
Mar 4, 2008·Biological & Pharmaceutical Bulletin·Chang-Seob SeoJong-Keun Son
Nov 29, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R AfsharA D Luster
Apr 29, 2010·Current Allergy and Asthma Reports·Devendra K Agrawal, Zhifei Shao
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Toshiaki AsanoYoshinori Hasegawa
Jul 10, 2010·Lung India : Official Organ of Indian Chest Society·Sudha S DeoPramod V Niphadkar
Nov 26, 2010·Biochemical and Biophysical Research Communications·David AdenugaIrfan Rahman
Dec 18, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ci XinxinDeng Xuming
Jan 31, 2012·The Journal of Allergy and Clinical Immunology·Joshua A BoyceMarc E Rothenberg
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Jul 25, 2013·Pharmacology & Therapeutics·Delphine GrasArnaud Bourdin
Aug 21, 2013·Nature Reviews. Immunology·J Simon C Arthur, Steven C Ley
Sep 14, 2013·Frontiers in Microbiology·Makoto KudoIchiro Aoki

❮ Previous
Next ❯

Citations

Aug 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna LeeHwan-Soo Yoo
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyeji ShinKi Yong Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.