Abstract
We have previously demonstrated the involvement of AP-1/Jun in fibroblast growth factor (FGF) signaling by loss-of-function assay (Dong, Z., Xu, R.-H., Kim, J., Zhan, S.-N., Ma, W.-Y., Colburn, N. H., and Kung, H. (1996) J. Biol. Chem. 271, 9942-9946). Further investigations by gain-of-function are reported in this study. AP-1 transactivation activity was increased by the treatment of animal cap explants with FGF. Ectopic overexpression of two components of AP-1 (c-jun and c-fos together, but not alone) produced posteriorized embryos and induced mesoderm formation in animal cap explants, indicating that both AP-1 heterodimers are required for mesoderm induction. Since Ras/AP-1 functions downstream of FGF signaling, we then tested the involvement of Ras/AP-1 in mesoderm maintenance mediated by embryonic FGF/Xbra using dominant-negative mutants. Mesoderm maintenance mediated by embryonic FGF/Xbra was blocked by dominant-negative mutants of Ras/AP-1, and AP-1 enhanced the expression of Xbra. Further studies demonstrated the inhibition of Ras/AP-1-mediated mesoderm formation by dominant-negative mutants of the FGF receptor and Xbra. These results indicate that Ras/AP-1 and FGF/Xbra signals are involved in the mesoderm maintenance m...Continue Reading
References
Nov 13, 1992·Cell·R S JohnsonV Papaioannou
Dec 24, 1992·Nature·Z Q WangE F Wagner
May 21, 1992·Nature·M Whitman, D A Melton
Jul 30, 1992·Nature·V Cunliffe, J C Smith
Jul 26, 1991·Cell·E AmayaM W Kirschner
Oct 4, 1991·Cell·J C SmithB G Herrmann
Dec 1, 1988·Genes & Development·F J RauscherT Curran
May 19, 1989·Science·M Whitman, D A Melton
Nov 18, 1988·Science·D KimelmanM W Kirschner
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·L M GravesD Kimelman
Jan 1, 1995·Current Biology : CB·S Schulte-Merker, J C Smith
Jul 6, 1995·Nature·M UmbhauerJ C Smith
Nov 1, 1995·Developmental Biology·J NorthropD Kimelman
Jul 6, 1995·Biochemical and Biophysical Research Communications·R H XuH F Kung
May 7, 1993·Cell·A M MacNicolL T Williams
Jan 27, 1995·Cell·C J Marshall
Oct 28, 1994·Science·D S Kessler, D A Melton
Feb 1, 1994·Current Biology : CB·J M Slack
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z DongN H Colburn
Jul 1, 1993·Genes & Development·R S JohnsonB M Spiegelman
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·R H XuH F Kung
Apr 26, 1996·The Journal of Biological Chemistry·Z DongH Kung
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TairaI B Dawid
Citations
Feb 5, 2003·Journal of Biomedical Science·Philip K Liu
Apr 3, 2002·Neuroscience·Y PengJ M Phang
Jul 24, 2012·The Journal of Biological Chemistry·Sung-Young LeeZigang Dong
Aug 11, 2011·PloS One·Sung-Young LeeJaebong Kim
Jan 15, 2008·Mechanisms of Development·Li YuanWalter Knöchel
Oct 25, 2000·Mechanisms of Development·S KnöchelW Knöchel
Apr 6, 2012·PloS One·Amanda L EvansJames C Smith
Nov 23, 2006·PLoS Genetics·Amer Ahmed RanaJ C Smith
Jan 6, 2007·PloS One·Chi ZhangMichael W Klymkowsky
Jun 9, 2016·Zoological Science·Hitoshi YoshidaAtsushi Suzuki
May 8, 2009·PLoS Biology·Steven A Harvey, James C Smith
Jan 30, 2013·PloS One·Cecilia E AguirreSilvia L López
Feb 27, 2009·PLoS Biology·Wouter BossuytBassem A Hassan
Jul 16, 2014·PLoS Biology·Noriaki SasaiJames Briscoe
Sep 20, 2011·Developmental Biology·Takeshi Noda
Dec 20, 2011·Developmental Biology·Mark KaliszPalle Serup
Feb 14, 2015·Genes & Diseases·Chad M TevenRussell R Reid
Sep 7, 2013·Developmental Biology·Rachel M WargaDonald A Kane
Oct 24, 2006·Developmental Biology·Dunja KnappJames C Smith
Jul 25, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R H XuH F Kung
Dec 7, 2002·The Journal of Biological Chemistry·Kaoru KawachiEisuke Nishida
Aug 1, 2018·Scientific Reports·Shiv KumarJaebong Kim
Nov 9, 2019·Genes·Shoshana Reich, Daniel C Weinstein
Feb 7, 2014·BMB Reports·Jaeho YoonJaebong Kim
Oct 10, 2020·Scientific Reports·Shiv KumarJaebong Kim
Feb 2, 2021·Cell Reports Medicine·Hadley E SheppardCharles Y Lin
Jan 12, 1999·Developmental Biology·A IulianellaD Lohnes
Aug 28, 2021·Cells·Vijay KumarJaebong Kim