Mesolimbic 7-OH-DPAT affects locomotor activities in rats

Pharmacology, Biochemistry, and Behavior
M E Meyer

Abstract

This study tested the hypotheses that the dopamine D3 receptor is both an autoreceptor and a postsynaptic receptor and has an affinity for dopamine at the nanomolar level. The effect of bilateral microinjections of a dopamine D3-like agonist, 7-OH-DPAT, into the nucleus accumbens and into the ventral tegmental area (VTA) was tested with rats in activity monitors. Horizontal movement, rearing, and stereotypy times in seconds were automatically measured during 12 consecutive 10-min time blocks. Intraaccumbens 7-OH-DPAT (0.0001-10.0 micrograms/side) resulted in a highly significant dose by time block interactions. The dose of 0.0001 microgram/side resulted in the potentiation of horizontal movement time during the time blocks 10-40 min; whereas, 0.001-1.0 microgram/side potentiated locomotion during the early blocks following the 10-min interval. However, 10.0 micrograms/side resulted in a biphasic effect, attenuation followed by potentiation. 7-OH-DPAT (0.0001-1.0 microgram/ side) potentiated rearing time in the early time blocks and (0.001-10.0 micrograms/side) attenuated stereotypy time during the first 20 min time blocks. On the other hand, intra-VTA 7-OH-DPAT (10.0 micrograms/side) attenuated horizontal movement time during t...Continue Reading

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D LévesqueP Sokoloff
Feb 11, 1992·Trends in Pharmacological Sciences·D R Sibley, F J Monsma
Apr 7, 1992·European Journal of Pharmacology·C Van HartesveldtM E Meyer
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Lynch
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 3, 1994·European Journal of Pharmacology·J C LiuB L Waszczak
Jan 1, 1994·Journal of Neural Transmission. General Section·K SvenssonN Waters
Nov 2, 1993·European Journal of Pharmacology·E MellerD A Basham
Jun 1, 1994·Trends in Pharmacological Sciences·J E FreedmanG J Greif
Jul 1, 1994·Trends in Pharmacological Sciences·P Seeman, H H Van Tol
Aug 1, 1993·Clinical Neuropharmacology·J C SchwartzP Sokoloff
Jan 1, 1993·Journal of Neural Transmission. General Section·N WatersA Carlsson
Feb 1, 1994·Trends in Pharmacological Sciences·C H Large, C M Stubbs

❮ Previous
Next ❯

Citations

Feb 1, 2005·Neurotoxicology and Teratology·Sonya K SobrianR Robert Holson
Jul 12, 2005·Neuropharmacology·Robert L H Clements, Andrew J Greenshaw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.