Mesolimbic dopamine and early post-6-OHDA lesion enhanced responses to d-amphetamine

Pharmacology, Biochemistry, and Behavior
M R Lynch, R J Carey

Abstract

Bilateral lesions of mesolimbic dopamine (DA) reliably produce an attenuated response to amphetamine's locomotor stimulatory effects when administered after two weeks of surgical recovery. Several studies have revealed enhanced amphetamine-induced hyperactivity during the first postlesion week, however. In the present study, animals with bilateral 6-OHDA lesions of nucleus accumbens and olfactory tubercle DA showed an exaggerated response to 1.0 mg/kg amphetamine during this early period but were hypoactive in the absence of drug treatment. Neurochemical assay at 5 days revealed increased DA metabolism in the tubercle. Shifting patterns of postlesion amphetamine response under conditions of reduced mesolimbic DA are suggestive of dynamic adaptations in nondopaminergic systems.

References

Jan 1, 1976·European Journal of Pharmacology·A J PijnenburgJ M Van Rossum
Oct 15, 1978·European Journal of Pharmacology·D WirtshafterE W Kent
Feb 1, 1989·Behavioural Brain Research·M R Lynch, R J Carey
Jan 1, 1988·Neuropsychobiology·M R LynchR J Carey
Mar 18, 1985·Brain Research·E Garcia-RillJ A Fitzgerald
Mar 15, 1972·Experientia·N E AndénU Ungerstedt
Nov 1, 1981·Behavioural Brain Research·G F KoobM Le Moal

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