Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

Behavioural Brain Research
Katayoun SedaghatSara Choobdar

Abstract

Depression, a common mood disorder, involves anhedonia and defects in reward circuits and mesolimbic dopamine transmission in the striatum and nucleus accumbens (NAc). Active vitamin-D, (1,25-(OH)2 vitamin-D3), exerts protective and regulatory effects on the brain dopamine system. In this study, key depression-like symptoms were induced in rats by chronic mild-stress (CMS) and the comparative effect of treatment with 1,25-(OH)2 vitamin-D3 (5, 10 μg/kg, or vehicle; i.p., twice weekly) or fluoxetine (5 mg/kg or vehicle, i.p., daily) on anhedonic behavior, locomotor activity and anxiety-like behavior was examined using sucrose preference test (SPT), open field test (OFT) and novel object exploration test (NOT), respectively. We also measured serum corticosterone levels and dopamine transporter-immunoreactivity (DAT-ir) levels in NAc shell and core. CMS exposure for 3 weeks was followed by a SPT and thereafter CMS was continued for 5 weeks, along with vitamin-D or fluoxetine treatment and further testing, which was concluded with another SPT. Vitamin-D treatment enhanced sucrose preference (P < 0.01; an hedonic effect) and increased object exploration (P < 0.01) in CMS rats. CMS significantly reduced the level of DAT-ir in NAc (P <...Continue Reading

Citations

May 17, 2019·CNS Drugs·Gleicilaine A S CassebAna Lúcia S Rodrigues
Nov 22, 2020·Journal of Neurology·Félix Javier Jiménez-JiménezElena García-Martín
Feb 9, 2021·JBMR Plus·Darryl Walter Eyles
Mar 11, 2021·Neuropsychiatric Disease and Treatment·Lobna A SalehYusuf S Althobaiti
Apr 23, 2021·Pathology, Research and Practice·Sinan LiuRongrong Jing
Aug 7, 2021·Genes, Brain, and Behavior·Hao GuoYunpeng Wang

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