Mesonephros has a role in limb development and is related to thalidomide embryopathy

Teratology
D M SmithT D Stephens

Abstract

Recent studies have demonstrated a link between limb reduction defects and mesonephros removal [Geduspan and Solursh, 1992) Dev. Biol., 151:242-250]. However, there is some question as to whether the limb-reduction defects seen in that study resulted from the removal of mesonephros or from the formation of scar tissue medial to the limb territory. The current study was conducted to test the hypothesis that elimination of the mesonephros without producing scar tissue adjacent to the limb will adversely affect limb morphogenesis. The hypothesis was tested by the insertion of tantalum foil barriers into various levels of the intermediate mesoderm of developing chick embryos to prevent the caudal elongation of the mesonephros. Limb reduction defects were obtained when the mesonephros was prevented from forming caudal to somite 14. No limb defects were seen when a foil barrier was placed into the intermediate mesoderm at the level of somite 21 or 25. Our results support the notion that a signal from the mesonephros is necessary for normal limb development. In addition, it appears that a craniocaudal factor emanating from the mesonephros plays a role in limb development. The limb reduction defects obtained in this study were also com...Continue Reading

References

Sep 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J S GeduspanM Solursh
Jun 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Duboule
May 1, 1992·Developmental Biology·J S Geduspan, M Solursh
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Del Rio-TsonisP A Tsonis
May 1, 1989·Developmental Biology·T D StephensH J Willis
Feb 3, 1973·British Medical Journal·R W Smithells
Oct 1, 1973·Teratology·T KajiiK Takahashi
May 1, 1972·Developmental Biology·J W Lash, L Saxén
Jan 1, 1965·Humangenetik·E Nowack
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Feb 1, 1959·The Journal of Experimental Zoology·S CHAUBE
Jan 1, 1945·Genetics·S Gluecksohn-Schoenheimer
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON
Jun 1, 1991·Journal of Morphology·Trent D StephensKirk P Winger

❮ Previous
Next ❯

Citations

Nov 19, 2015·Journal of the American Academy of Dermatology·Divya Sharma, Shawn G Kwatra
Aug 19, 2004·American Journal of Medical Genetics. Part a·Hester Y KroesMartina C Cornel
Aug 10, 2005·The British Journal of Dermatology·J J WuS K Tyring
Aug 1, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Trent D Stephens
Jul 31, 2007·Development, Growth & Differentiation·Kazuna Sato, Ellen A G Chernoff
Sep 23, 1997·Developmental Biology·M Fernandez-TeranM A Ros
Jul 11, 1998·Clinical Genetics·J W Innis, D P Mortlock
Jul 10, 2021·Birth Defects Research·Lewis B Holmes, Hanah Z Nasri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.