Mesophilic Aeromonas sp. serogroup O:11 resistance to complement-mediated killing.

Infection and Immunity
S MerinoJ M Tomás

Abstract

The complement activation by and resistance to complement-mediated killing of Aeromonas sp. strains from serogroup O:11 were investigated by using different wild-type strains (with an S-layer characteristic of this serogroup) and their isogenic mutants characterized for their surface components (S-layer and lipopolysaccharide [LPS]). All of the Aeromonas sp. serogroup O:11 wild-type strains are unable to activate complement, which suggested that the S-layer completely covered the LPS molecules. We found that the classical complement pathway is involved in serum killing of susceptible Aeromonas sp. mutant strains of serogroup O11, while the alternative complement pathway seems not to be involved, and that the complement activation seems to be independent of antibody. The smooth mutant strains devoid of the S-layer (S-layer isogenic mutants) or isogenic LPS mutant strains with a complete or rather complete LPS core (also without the S-layer) are able to activate complement but are resistant to complement-mediated killing. The reasons for this resistance are that C3b is rapidly degraded, and therefore the lytic membrane attack complex (C5b-9) is not formed. Isogenic LPS rough mutants with an incomplete LPS core are serum sensitive...Continue Reading

References

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Citations

Jan 1, 2012·ISRN Microbiology·J M Tomás
Aug 29, 2009·Journal of Medical Microbiology·Poulami BhowmikT Ramamurthy
Dec 3, 1999·Microbes and Infection·A K Chopra, C W Houston
Jul 4, 2003·Applied and Environmental Microbiology·Thomas R BraschlerJoerg Graf
Oct 7, 2004·Applied and Environmental Microbiology·Consuelo EsteveJuan M Tomás
Jan 13, 2010·Clinical Microbiology Reviews·J Michael Janda, Sharon L Abbott
Nov 29, 2011·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Tomohiro Iwakura, Shigehiko Yoshida
Nov 26, 2021·Marine Drugs·Elena Mendoza-BarberáJuan Tomás

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