Mesoporous platinum nanoparticle-based nanoplatforms for combined chemo-photothermal breast cancer therapy

Journal of Colloid and Interface Science
Bei FuYuxia Tang

Abstract

High-efficiency cancer treatment remains the main challenge at present. In this study, a mesoporous platinum nanoparticle- (mesoPt) based nanoplatform is exported for effective tumor treatment, integrating computed tomography (CT) imaging, photothermal conversion, and chemotherapeutic drug delivery capabilities. Mesoporous platinum nanoparticles are facilely synthesized by using Pluronic F127 as a structure-directing agent without seeds or organic reagents and have a spherical structure and uniform diameter of 94 nm. The surface of the mesoPt is modified with polyethylene glycol (PEG), and the prepared mesoPt-PEG shows excellent biocompatibility. Doxorubicin (Dox)-loaded PEG@Pt (PEG@Pt/Dox) is further prepared by electrostatic adsorption and the drug-loading capacity is as high as 25%. In vitro studies demonstrate that Dox can be controllably released from PEG@Pt/Dox in pH 5.5 phosphate buffered solution (PBS). Confocal imaging verifies that PEG@Pt/Dox can efficiently enter Dox-resistant breast cancer cells (MCF-7/ADR), deliver Dox into the cytoplasm when incubated for 1 h or 12 h, and release Dox into the nucleus when incubation is prolonged to 24 h. Cell transmission electron microscopy and flow cytometry also confirm that PE...Continue Reading

Citations

Jan 29, 2021·Frontiers in Molecular Biosciences·Adityanarayan MohapatraIn-Kyu Park
Feb 21, 2021·Journal of Colloid and Interface Science·Xiaoling RenZhigang Chen
Jul 30, 2020·Journal of Colloid and Interface Science·Rui XiaZhigang Xie
Jun 3, 2021·Pharmaceutics·Yuseon ShinKyungtaek Oh
Aug 29, 2021·Pharmaceutics·Kazi Mustafa MahmudMd Asiful Islam

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