Mesoporous silica aerogel as a drug carrier for the enhancement of the sunscreen ability of benzophenone-3

Colloids and Surfaces. B, Biointerfaces
C C LiY W Chen-Yang

Abstract

In the present study, about 45 and 34 wt% of benzophenone-3 (BP-3), an organic UV filter, was adsorbed on a high surface area mesoporous silica (MS) drug carrier to prepare BP-3-bearing MS (MSBP) sunscreen materials MSBP-1 and MSBP-2, respectively. The effect of the adsorption of BP-3 by MS on the UV protection ability of MSBP was demonstrated and a synergistic UV protection effect was observed in the as-prepared MSBP UV filters. Compared with free BP-3, adsorbed BP-3 had greatly reduced crystallinity and the dispersion of MSBP was significantly improved in the sunscreen. The in vitro sun protection factor (SPF) and in vitro UV-A values of the MSBP-2-based sunscreen was about 17.3% and 17.0% higher than that of free BP-3-based sunscreen, respectively, indicating that the ability of the sunscreen to protect against UV-B and UV-A improved because of the BP-3 content of the MS matrix. In addition, the decrease in SPF and UV-A values over time was significantly less in the MSBP-based sunscreens than in free BP-3-based sunscreen. Results of this study reveal that MS is a promising organic sunscreen carrier as well as a potential carrier for other topical drugs.

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Citations

Aug 15, 2019·Nanomedicine·Francisco ArriagadaJavier Morales
Nov 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun ZhangChengzhong Yu
Aug 23, 2019·International Journal of Pharmaceutics·André Luis Máximo DanelutiYogeshvar N Kalia
Nov 27, 2021·Environmental Science and Pollution Research International·Hakimeh TeiriRoya Kelishadi

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