Mesoporous silica nanoparticle is comparatively safer than zinc oxide nanoparticle which can cause profound steroidogenic effects on pregnant mice and male offspring exposed in utero

Toxicology and Industrial Health
Nisha BaraGautam Kaul

Abstract

The increasing use of nanomaterials has naturally caused heightened concerns about their potential risks to human and animal health. We investigated the effect of zinc oxide nanoparticles (ZnO NPs) and mesoporous silica nanoparticles (MSN) on steroidogenesis in the corpus luteum (CL) of pregnant mice and testis of male offspring. Pregnant albino mice were exposed to ZnO NPs and MSN for 2 days on alternate days, gestation days 15-19. Hepatic injury marker enzymes increased in the higher concentration of NM-exposed mother mice, but histological examination revealed no changes in the placenta of pregnant mice, whereas testis of male offspring showed gross pathological changes. The expression pattern of progesterone biosynthesis-related genes was also altered in the CL of NP-exposed pregnant mice. In utero exposure of ZnO NPs increased the relative expression of StAR in 100 mg/kg body weight (BW) ZnO NP-treated and bulk ZnO-treated groups and P450 side-chain cleavage enzyme (P450scc) in 50 mg/kg BW ZnO NP-treated and 100 mg/kg of bulk ZnO-treated male offspring. Serum testosterone concentration significantly increased in the 100 mg/kg of bulk ZnO-treated group and decreased in the 250 mg/kg of MSN-treated group and a single dose of...Continue Reading

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Citations

Mar 19, 2020·Critical Reviews in Toxicology·S Keerthana, A Kumar
Mar 27, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Shahla ShojaeiHagar I Labouta
Apr 4, 2021·Nanomaterials·Chuanfeng TengShumei Zhai
Jun 8, 2021·Reproductive Toxicology·Ramsés Santacruz-MárquezIsabel Hernández-Ochoa
Dec 23, 2021·Journal of Applied Toxicology : JAT·Yongshuai Yao, Meng Tang

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