Mesoporous Silica Nanoparticles-Encapsulated Agarose and Heparin as Anticoagulant and Resisting Bacterial Adhesion Coating for Biomedical Silicone

Langmuir : the ACS Journal of Surfaces and Colloids
Fan WuJian Shen

Abstract

Silicone catheter has been widely used in peritoneal dialysis. The research missions of improving blood compatibility and the ability of resisting bacterial adhesion of silicone catheter have been implemented for the biomedical requirements. However, most of modification methods of surface modification were only able to develop the blood-contacting biomaterials with good hemocompatibility. It is difficult for the biomaterials to resist bacterial adhesion. Here, agarose was selected to resist bacterial adhesion, and heparin was chosen to improve hemocompatibility of materials. Both of them were loaded into mesoporous silica nanoparticles (MSNs), which were successfully modified on the silicone film surface via electrostatic interaction. Structures of the mesoporous coatings were characterized in detail by dynamic light scattering, transmission electron microscopy, Brunauer-Emmett-Teller surface area, thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscope, and water contact angle. Platelet adhesion and aggregation, whole blood contact test, hemolysis and related morphology test of red blood cells, in vitro clotting time tests, and bacterial adhesion assay were performed to evaluate the a...Continue Reading

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Citations

Dec 19, 2018·Pharmaceutics·Marina Martínez-CarmonaMaría Vallet-Regí
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Oct 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingyu GuoHeran Li
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May 13, 2020·Pharmaceutics·Rafael R CastilloMaría Vallet-Regí
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Sep 25, 2018·International Journal of Biological Macromolecules·Zahra RoshanfekrnahzomiMojtaba Falahati
Aug 11, 2021·Pharmaceutics·Elham RastegariYueh Chien

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