Mesoporous silica/apatite nanocomposite: special synthesis route to control local drug delivery

Acta Biomaterialia
A SousaE M B Sousa

Abstract

Synthetic hydroxyapatite is widely used in medicine and dentistry due its notable biocompatibility and bioactivity properties. The hydroxyapatite incorporation into silica has demonstrated excellent bioactivity or biodegradability, according to the content of calcium ions. Procedures to obtain ordered mesoporous silicates rely on the micelle-forming properties of a surfactant, whose chemical composition, size and concentration control the structural dimensions of the final material. This paper reports the synthesis of two types mesoporous materials: pure MCM-41 and a nanocomposite of apatite and mesoporous silica, MCM-41-HA. The samples were charged with atenolol as a model drug and in vitro release essays were carried out. The bioactivity behavior was investigated as a function of soaking time in simulated body fluid. The materials were characterized by X-ray diffraction, N2 adsorption, FTIR spectroscopy, scanning electron microscopy, dispersive energies spectroscopy, and transmission electron microscopy. The influence of the release rate of atenolol molecules from pure MCM-41 mesoporous and containing hydroxyapatite was demonstrated, since it results in a very slowly drug delivery from the nanocomposite system.

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Citations

Oct 8, 2008·Journal of Materials Science. Materials in Medicine·K C SouzaE M B Sousa
Dec 24, 2013·Colloids and Surfaces. B, Biointerfaces·C C LiY W Chen-Yang
Jul 25, 2014·Journal of Materials Science. Materials in Medicine·Gracielle Ferreira AndradeEdésia Martins Barros de Sousa
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Maykel GonzálezRogelio Rodríguez
Jul 31, 2012·Acta Biomaterialia·Johan KarlssonMartin Andersson
Oct 27, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed S Al-KadyEl-Zeiny M Ebeid
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Fozia RehmanPedro L O Volpe
Oct 17, 2015·Journal of Medicinal Chemistry·Yan-Jye ShyongFeng-Huei Lin
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·L S MendesR Marchetto
Sep 20, 2012·International Journal of Pharmaceutics·Thuy Thi Thu NguyenJun Seo Park
Oct 14, 2019·Journal of Materials Science. Materials in Medicine·Ali AleneziAnn Wennerberg
Jan 20, 2012·Beilstein Journal of Nanotechnology·Jarian VernimmenPegie Cool
Feb 7, 2020·Pharmaceutical Development and Technology·Legha AnsariBizhan Malaekeh-Nikouei
Dec 27, 2011·Nanoscale·Amirali PopatShi Zhang Qiao
Jul 30, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Noritaka KatoShouzou Koumoto

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