Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Stefan S KachalaPrasad S Adusumilli

Abstract

In an effort to identify molecular markers of tumor aggressiveness and therapeutic targets in lung adenocarcinoma (ADC), we investigated the expression of mesothelin (MSLN) in lung ADC, as well as its biologic and clinical relevance. In a training and validation set of patients with early-stage (I-III) lung ADC (n = 1,209), a tissue microarray consisting of tumors and normal lung tissue was used to examine the association between MSLN expression and recurrence-free survival (RFS) and overall survival (OS). The influence of MSLN overexpression on lung ADC was investigated in vitro and in vivo by use of clinically relevant orthotopic and metastatic xenogeneic and syngeneic mouse models. MSLN was expressed in 69% of lung ADC tumors, with one in five patients strongly expressing MSLN and no expression in normal lung tissue. Increased MSLN expression was associated with reduced OS [HR = 1.78; 95% confidence interval (CI), 1.26-2.50; P < 0.01] and RFS (HR = 1.67; 95% CI, 1.21-2.27; P < 0.01) in multivariate analyses, even after adjustment for currently known markers of tumor aggressiveness in lung ADC: male sex, smoking history, increasing stage, morphologic pattern, visceral pleural invasion, lymphatic or vascular invasion, and muta...Continue Reading

References

Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raffit HassanIra Pastan
May 19, 2005·International Journal of Cancer. Journal International Du Cancer·Susan S DevesaD Max Parkin
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitchell HoIra Pastan
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfonso CristaudoRiccardo Puntoni
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raffit HassanIra Pastan
Oct 20, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raffit Hassan, Mitchell Ho
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jenifer L MarksWilliam Pao
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carmine CarpenitoCarl H June
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra P D'AngeloMark G Kris
May 31, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha RekhtmanAndre L Moreira
Nov 3, 2011·PloS One·Elliot L ServaisPrasad S Adusumilli
Dec 1, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Evripidis LanitisDaniel J Powell
Jan 13, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nabil P RizkPrasad S Adusumilli
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elliot L ServaisPrasad S Adusumilli
Mar 16, 2012·Breast Cancer Research and Treatment·Julia TchouPaul J Zhang
Jul 4, 2012·The Lancet Oncology·Anish Thomas, Raffit Hassan

❮ Previous
Next ❯

Citations

Mar 5, 2016·Journal of Experimental & Clinical Cancer Research : CR·Emmanuel ZervosRachel L Roper
Oct 31, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marissa MayorPrasad S Adusumilli
May 24, 2016·Expert Review of Anticancer Therapy·Anish Thomas
Sep 24, 2016·American Journal of Surgery·Masha ZeltsmanPrasad S Adusumilli
Jul 28, 2016·The Journal of Clinical Investigation·Leonid CherkasskyPrasad S Adusumilli
Aug 24, 2016·Nature Reviews. Cancer·Andrew D FesnakBruce L Levine
Mar 28, 2017·Journal of Surgical Oncology·Carl J DeSelmPrasad S Adusumilli
Mar 31, 2017·Journal of Hematology & Oncology·Shengnan YuKongming Wu
Jul 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaoqing HeYon Rojanasakul
Jan 10, 2018·Frontiers in Immunology·Hamid R MirzaeiBehnam Badie
Oct 16, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Karolina OkłaIwona Wertel
Apr 30, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Robin MyteSophia Harlid
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Oladapo YekuRenier J Brentjens
Aug 30, 2019·Biomarker Research·Jiang Lv, Peng Li
Mar 7, 2019·Nature Reviews. Clinical Oncology·Nirali N Shah, Terry J Fry
Oct 2, 2020·Cellular & Molecular Immunology·Jianshu WeiWeidong Han
Jul 23, 2018·Journal of Experimental & Clinical Cancer Research : CR·Michelle H TownsendKim L O'Neill
Oct 17, 2018·Archives of Gynecology and Obstetrics·Korinna JöhrensGuenter Cichon
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Elliot L ServaisPrasad S Adusumilli
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Mitchell HoIra Pastan
HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Zachary W KendrickSean J Mulvihill
The Journal of International Medical Research
Y WangQ F Chen
© 2021 Meta ULC. All rights reserved