Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein

Diabetologia
S E LallyG H Tomkin

Abstract

The aim of the present study was to examine the relationship between chylomicron composition and expression of genes that regulate chylomicron production in the intestine. We examined expression of the following: (1) Niemann-Pick C1-like 1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8), which regulate cholesterol homeostasis through their ability to excrete enterocyte cholesterol back into the lumen of the intestine; and (3) microsomal triglyceride transfer protein (MTTP), which packages the chylomicron particle by assembling cholesterol, triglyceride, phospholipids and apolipoprotein B48. Type 2 diabetic (26) and non-diabetic (21) patients were examined. Levels of NPC1L1, ABCG5 and ABCG8 and MTTP mRNA were measured in duodenal biopsies by real-time PCR. Lipoproteins were isolated by sequential ultracentrifugation. Diabetic patients had more NPC1L1 mRNA than the control subjects (p<0.02). Expression of ABCG5 and ABCG8 mRNA was lower in the diabetic patients (p<0.05) and MTTP expression was increased (p<0.05). There was a positive correlation between NPLC1L1 and MTTP mRNA (p<0.01) and a negative correlation between NPC1L1 and ABCG5 mRNA (p<0.001). Diabetic patient...Continue Reading

References

May 1, 1990·Diabetes·N M O'MearaG H Tomkin
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
Jan 1, 1997·Diabetes Care·H Gylling, T A Miettinen
Dec 2, 1999·Atherosclerosis·M M Hussain
Jul 27, 2001·International Journal of Experimental Diabetes Research·A GleesonG H Tomkin
Jun 22, 2002·Metabolism: Clinical and Experimental·Catherine PhillipsGerald H Tomkin
Dec 3, 2002·International Journal of Experimental Diabetes Research·Catherine PhillipsGerald H Tomkin
Feb 4, 2003·Journal of Lipid Research·Nirupa R MatthanAlice H Lichtenstein
Mar 21, 2003·Metabolism: Clinical and Experimental·Grace J PetotRobert P Friedland
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G F WattsG R Thompson
Nov 26, 2003·European Journal of Clinical Investigation·T A Miettinen, H Gylling
Dec 19, 2003·Metabolism: Clinical and Experimental·Christiane A GelukManuel Castro Cabezas
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano
May 12, 2004·Atherosclerosis·Nirupa R Matthan, Alice H Lichtenstein
Jun 4, 2004·Journal of Lipid Research·Helena GyllingTatu A Miettinen
Jan 13, 2005·Journal of Atherosclerosis and Thrombosis·Akira Tanaka
May 14, 2005·Current Opinion in Lipidology·M Mahmood HussainJahangir Iqbal

❮ Previous
Next ❯

Citations

Dec 15, 2007·Pharmaceutical Research·Yuki IwayanagiHiroshi Suzuki
Oct 19, 2010·Pharmaceutical Research·Yuki IwayanagiHiroshi Suzuki
May 8, 2008·Current Opinion in Lipidology·Liqing Yu
Dec 25, 2008·Current Opinion in Lipidology·Gerald H Tomkin
Nov 14, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Emilie GrenierEmile Levy
Mar 3, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sabina Paglialunga, Katherine Cianflone
Apr 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pradeep KumarWaddah A Alrefai
Nov 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pooja MalhotraWaddah A Alrefai
Oct 19, 2011·International Journal of Vascular Medicine·Gerald H Tomkin, Daphne Owens
Oct 3, 2008·The Journal of Clinical Investigation·Kevin Jon Williams
Dec 3, 2010·Journal of Lipid Research·André J TremblayPatrick Couture
May 11, 2010·PloS One·Christiaan J MassonMaurice M A L Pelsers
Feb 17, 2010·Clinical Drug Investigation·Yasunori SawayamaJun Hayashi
Jul 2, 2008·Internal Medicine·Shin-ichiro Miura, Keijiro Saku
Jul 19, 2012·World Journal of Gastroenterology : WJG·Alan B R ThomsonHugh Freeman
Jan 16, 2010·Journal of Atherosclerosis and Thrombosis·Shinya HiramitsuYukio Ozaki
Jul 7, 2010·Expert Review of Cardiovascular Therapy·Gerald H Tomkin
Mar 24, 2010·FEBS Letters·Jenna L Betters, Liqing Yu
Feb 13, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Josep JulveFrancisco Blanco-Vaca
Sep 4, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Juan Patricio Nogueira, Fernando Daniel Brites
Oct 18, 2011·Biochimica Et Biophysica Acta·Changting Xiao, Gary F Lewis
May 4, 2010·Atherosclerosis. Supplements·Gerald H Tomkin
Mar 11, 2009·Biochimica Et Biophysica Acta·Harry R Davis, Scott W Altmann
Aug 12, 2008·Atherosclerosis. Supplements·Gerald H Tomkin
Aug 12, 2008·Atherosclerosis. Supplements·Katherine CianfloneChristian Roy
Mar 28, 2012·Journal of Diabetes Investigation·Shinji IchimoriEiichi Araki
Aug 23, 2011·Biochimica Et Biophysica Acta·Jesús Méndez-GonzálezJoan Carles Escolà-Gil
Mar 5, 2011·The Journal of Medical Investigation : JMI·Miyako KishimotoMitsuhiko Noda
Feb 17, 2015·The British Journal of Nutrition·Els De SmetJogchum Plat
Feb 26, 2015·Diabetes Technology & Therapeutics·Takashi KatsuraKeisuke Kosugi
Apr 24, 2013·Progress in Lipid Research·Miriam Lee-RueckertJoan Carles Escola-Gil
Jul 22, 2008·Journal of cardiology·Shin-ichiro Miura, Keijiro Saku

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.