MET amplification, protein expression, and mutations in pulmonary adenocarcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Seongyeol ParkDae Seog Heo

Abstract

MET amplification, protein expression, and splice mutations at exon 14 are known to cause dysregulation of the MET/HGF pathway. Our study aimed to confirm the relationship among MET amplification, protein expression, and mutations in pulmonary adenocarcinoma. MET protein expression by immunohistochemistry (IHC) and MET amplification by fluorescence in situ hybridization (FISH) were evaluated in 316 surgically resected lung adenocarcinomas. Patients were divided into 4 groups (IHC-negative/FISH-negative, IHC-negative/FISH-positive, IHC-positive/FISH-negative, and IHC-positive/FISH-positive), and 15-20 tumors in each group were randomly selected for mutation analyses to find splice mutations at exon 14. An IHC score of 0-3 was found in 168 (53.2%), 71 (22.5%), 59 (18.7%), and 18 (5.7%) tumors, respectively. The mean gene copy number (GCN) was 3.56; MET FISH positivity was detected in 123 (38.9%) samples, and 26 (8.2%) of them were gene amplifications. MET amplification were significantly associated with the IHC score (P<0.001, χ(2) test). Splice mutations were identified in only 2 (2.9%) of 70 cases. One had a MET IHC score of 2 and negative FISH without amplification; The other had a MET IHC score of 0 and positive FISH without ...Continue Reading

References

May 11, 1989·Nature·S GiordanoP M Comoglio
Aug 12, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M S TsaoH Zhu
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Carmen BirchmeierGeorge F Vande Woude
Jan 7, 2006·Cancer Research·Monica Kong-BeltranRobert Yauch
Apr 27, 2007·Cancer Science·Yu NakamuraMasashi Fukayama
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ryoichi OnozatoTetsuya Mitsudomi
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico CappuzzoMarileila Varella-Garcia
Jan 29, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Heounjeong GoDoo Hyun Chung
Feb 13, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takamitsu OnitsukaKosei Yasumoto
Jul 8, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aya TanakaShinya Kimura
Jul 23, 2011·Pathology Oncology Research : POR·Mukaddes GumustekinNese Atabey
Aug 30, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Keisei TachibanaMasayuki Noguchi
Nov 5, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ya-Ting ChenShiu-Feng Huang
Dec 27, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Koji TsutaHitoshi Tsuda
Jan 13, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rafal DziadziuszkoFred R Hirsch
Jan 25, 2012·Nature Reviews. Cancer·Ermanno GherardiGeorge Vande Woude
May 31, 2013·Journal of Biomedical Research·Wenze SunJie Cui
Jul 12, 2013·American Journal of Respiratory and Critical Care Medicine·Stephanie Cardarella, Bruce E Johnson
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R SpigelAmy C Peterson
Dec 29, 2013·Japanese Journal of Clinical Oncology·Seiji Yano, Takayuki Nakagawa

❮ Previous
Next ❯

Citations

Jul 23, 2016·Molecular Medicine·Havva O KilgozBahar Taneri
Oct 13, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Seulki KimDae Seog Heo
Nov 22, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Roberta CastiglioneAnne Maria Schultheis
Jul 4, 2020·Expert Opinion on Emerging Drugs·Toshio FujinoTetsuya Mitsudomi
Mar 20, 2018·Oncogene·Leslie DuplaquetDavid Tulasne
Jun 10, 2020·Nature Reviews. Clinical Oncology·Robin GuoAlexander Drilon
May 5, 2021·Expert Opinion on Therapeutic Targets·Matthew LeeBalazs Halmos
Feb 5, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Wonyoung ChoiJi-Youn Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.