MET exon 14 splicing sites mutations: A new therapeutic opportunity in lung cancer

Revue des maladies respiratoires
Simon BaldacciAlexis B Cortot

Abstract

The mutations leading to MET exon 14 skipping represent a new class of molecular alterations described in various cancers. These alterations are observed in 2 to 3 % of cases of non-small cell lung cancer (NSCLC). Several cases of NSCLC carrying such alterations and achieving objective response to MET tyrosine kinase inhibitorshave recently been published. This review summarizes the molecular mechanisms responsible for MET exon 14 skipping as well as the consequences of the loss of this exon on receptor activity. We also describe the clinical characteristics of patients with METΔ14 mutations. Finally, we address the issues related to the detection of these mutations in lung cancer, and the need to anticipate resistance to MET inhibitors.

Citations

May 22, 2020·Frontiers in Cell and Developmental Biology·Xing HuangTingbo Liang
Oct 30, 2020·Journal of Experimental Pharmacology·Haidar El DarsaOmar Abdel-Rahman

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