Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer

Molecular Cancer
Mengqin ShenJianjun Liu

Abstract

TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway. The role of TIGAR in tumor cell invasion and metastasis remains elusive. Here we found that downregulation of TIGAR reduced the invasion and metastasis of NSCLC cells in vitro and in vivo. Immunohistochemical analysis of 72 NSCLC patients showed that TIGAR and Met protein expression was positively correlated with late stages of lung cancer. Besides, patients with high co-expression of TIGAR and Met presented a significantly worse survival. In addition, we found that Met signaling pathway is involved in TIGAR-induced invasion and metastasis. Our study indicates that TIGAR/Met pathway may be a novel target for NSCLC therapy. It is necessary to evaluate the expression of TIGAR before Met inhibitors are used for NSCLC treatment.

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Citations

Mar 3, 2019·International Journal of Molecular Sciences·Gabriele D MaurerJoachim P Steinbach
Nov 6, 2018·Journal of Cellular Physiology·Saeed SamarghandianTahereh Farkhondeh
Aug 18, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Yu-Shui MaDa Fu
Nov 20, 2018·Frontiers in Oncology·Weifen ZhangWentong Li
Dec 14, 2018·Journal of Cellular Physiology·Xin GongSunXiangYan Liu
Aug 23, 2019·Cellular and Molecular Life Sciences : CMLS·Jinshou YangYupei Zhao
Jun 3, 2021·International Journal of Molecular Sciences·Se-Hwa JungPyung-Hwan Kim

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Methods Mentioned

BETA
Antibody Sampler
PCR
electrophoresis
transfection
xenografts
Flow cytometry
nuclear translocation
Immunoprecipitation
Trans-well

Software Mentioned

Graphpad Prism
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