MET overexpression and gene amplification: prevalence, clinico-pathological characteristics and prognostic significance in a large cohort of patients with surgically resected NSCLC

Virchows Archiv : an International Journal of Pathology
William SterlacciAlexandar Tzankov

Abstract

The prevalence of overexpression and amplification of the proto-oncogene mesenchymal epithelial transition (MET) in non-small cell lung cancer (NSCLC) varies greatly in the literature. Since MET is a potential treatment target, knowledge of its prevalence and prognostic importance is crucial. We investigated MET expression and gene status in 735 NSCLC cases using tissue microarrays. Prognostic significance as well as correlations with various clinico-pathological parameters were evaluated. The prevalence of MET overexpression was 17% and MET amplification was present in 2.4% of cases. MET overexpression was found more frequently in adenocarcinomas (and TTF1-positive tumors) and female patients and was also associated with expression of members of the epidermal growth factor receptor (EGFR) signaling cascade. MET amplified tumors tended to express MET more frequently and more intensively. MET expression or gene status did not prove to be relevant prognostic factors. MET may not be an unequivocal prognostic parameter; however, its expression is associated with certain clinico-pathological characteristics and with EGFR and downstream EGFR effectors. This could be an important point for future studies addressing targeted MET therap...Continue Reading

References

May 11, 1989·Nature·S GiordanoP M Comoglio
Jul 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William SterlacciAlexandar Tzankov
Dec 27, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Koji TsutaHitoshi Tsuda
Jan 13, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rafal DziadziuszkoFred R Hirsch
Jan 25, 2012·Nature Reviews. Cancer·Ermanno GherardiGeorge Vande Woude
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R SpigelAmy C Peterson
May 24, 2014·British Journal of Cancer·N CihoricC Tapia
Jan 8, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Florian KocherMichael Fiegl
Jan 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark M AwadLynette M Sholl
Jan 23, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna LiYi-Long Wu
Jan 23, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seongyeol ParkDae Seog Heo

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Citations

Mar 9, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laetitia LambrosArnaud Uguen
Aug 2, 2019·Expert Review of Anticancer Therapy·Johan Filip VansteenkistePierre Van Mol
Sep 13, 2019·Critical Reviews in Clinical Laboratory Sciences·Fatemeh MoosaviOmidreza Firuzi
May 7, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·William SterlacciAlexandar Tzankov
Sep 2, 2017·Virchows Archiv : an International Journal of Pathology·Laetitia LambrosArnaud Uguen
Sep 8, 2017·Virchows Archiv : an International Journal of Pathology·William SterlacciSpasenija Savic
Jul 2, 2020·OncoTargets and Therapy·Olivier BylickiChristos Chouaïd
Dec 7, 2019·Current Problems in Cancer·Murugesan SivakumarSivakumar Loganathan

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