Meta-analyses of RELN variants in neuropsychiatric disorders

Behavioural Brain Research
Na ChenJie Shi

Abstract

Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also been reported to be associated with several psychiatric disorders, but the results remain controversial. Here, we conducted meta-analyses of RELN gene SNPs and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders). A total of 12 SNPs (rs736707, rs362691, rs607755, rs2229864, rs7341475, rs262355, rs362719, rs11496125, g.-888G>C, rs2299356, rs528528, and rs4298437) in RELN gene were included into meta-analyses. Subgroup analyses based on ethnicity were performed. We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01). No association of other SNPs and psychiatric disorders is found. These findings suggest a role of...Continue Reading

References

Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hui LiZhengyan Zhao
Mar 13, 2014·BMC Psychiatry·Ho Jang KwonMyung Ho Lim

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Citations

Sep 6, 2020·Journal of Molecular Neuroscience : MN·Sadiatul MarzanMohammad Safiqul Islam
Apr 14, 2019·Molecular Biology Reports·Mavi Deniz SozuguzelMustafa Yildiz
Oct 20, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V AlfimovaV E Golimbet
Feb 2, 2019·BMC Medical Genomics·Seonggyun HanUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative
Jun 3, 2018·Molecular Psychiatry·Yanli Zhang-JamesStephen V Faraone
Oct 4, 2020·Brain Sciences·Jinhee LeePaolo Fusar-Poli
Sep 27, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Courtney D ThornburgUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

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