Meta-analyses using real-world data to generate clinical and epidemiological evidence: a systematic literature review of existing recommendations

Current Medical Research and Opinion
Jean-Baptiste BriereCraig Coleman

Abstract

To identify existing guidelines, key recommendations, and existing limitations regarding the evaluation and use of real-world evidence (RWE) in meta-analyses (MAs) to generate clinical and epidemiological evidence: a systematic review of existing recommendations. A literature search was performed in April 2017 in MEDLINE and Embase using the Ovid platform, the Cochrane Library, and other sources. No specific inclusion and exclusion criteria were applied, and no restrictions in timeframe, language, or geographical scope were imposed. The search strategy identified 1681 citations; 12 references were included in this review. Recommendations within the literature regarding the use of RWE in MAs are: (1) it may be useful to extract and analyze adjusted results because confounding is expected; (2) testing heterogeneity in the MA of RWE is important as it may minimize the potential for bias and generate hypotheses for future research; (3) limiting a search ≤2 bibliographic databases when conducting MAs of RWE will not provide a thorough summary of existing literature; and (4) the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) checklist is a 35-item checklist developed to allow for more standardized reporting of MAs of ...Continue Reading

References

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Citations

Jul 14, 2020·Journal of Medical Economics·Kevin BowrinAurélie Millier
Nov 20, 2019·Drugs -- Real World Outcomes·Andrew D XiaMatthew J Hirst
Dec 29, 2020·Acta Ophthalmologica·Robert P FingerJean-François Korobelnik
Jan 10, 2021·BMJ Open·Michail ArvanitidisEduardo Martinez-Valdes
Oct 20, 2019·The Journal of Allergy and Clinical Immunology·Jean BousquetUNKNOWN Allergic Rhinitis and Its Impact on Asthma Working Group
Aug 5, 2021·Applied Clinical Informatics·Vojtech HuserCraig S Mayer

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