Meta-analysis and the science of schizophrenia: variant evidence or evidence of variants?

Neuroscience and Biobehavioral Reviews
R W Heinrichs

Abstract

Quantification (meta-analysis) of the neuroscience evidence on schizophrenia shows very modest average differences between patient and control distributions across a great variety of measures and literatures. The strongest findings involve cognitive and psychophysiological measures. Several possible explanations for this situation are reviewed including technical immaturity, methodological variability, dimensional and multiple illness models and the nature of cognitive measurement. An argument is developed that biological subtypes and endophenotypes within the broad diagnostic category of schizophrenia underpin the meta-analytic evidence. Considerations in the use of this evidence to identify illness variants are described and four candidate subtypes are proposed. Schizophrenia is a disease that will resist biological definition until its variants are isolated and extracted from the generic patient population.

References

Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak
Jan 1, 1991·Schizophrenia Bulletin·S SzymanskiJ A Lieberman
May 1, 1991·Journal of Abnormal Psychology·W M GroveW G Iacono
May 1, 1988·The American Journal of Psychiatry·W T CarpenterA M Wagman
Aug 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·P F Liddle
Oct 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·A V Mackay
May 1, 1995·The American Journal of Psychiatry·S E ArnoldJ Q Trojanowski
Mar 1, 1993·Schizophrenia Research·R W Heinrichs, A G Awad
Oct 1, 1993·Archives of General Psychiatry·W T CarpenterF Wood
Aug 1, 1993·Schizophrenia Research·A K MallaF Diaz
Jan 15, 1993·Biological Psychiatry·C M ClarkD Li
Oct 1, 1995·Schizophrenia Research·T E Goldberg, D R Weinberger
Jul 1, 1996·Psychophysiology·D E RossK S Kendler
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·S A JönssonA Brun
Jan 1, 1997·Schizophrenia Bulletin·R R Conley, R W Buchanan
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·S M Lawrie, S S Abukmeil
Jun 24, 1998·Psychopathology·S Dollfus, B Everitt
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Aug 28, 1998·Schizophrenia Research·K K Zakzanis, K T Hansen
Apr 10, 1999·Archives of General Psychiatry·K O LimA Pfefferbaum
May 20, 1999·Biological Psychiatry·R W McCarleyM E Shenton
Oct 3, 1999·Schizophrenia Research·G W StuartI H Minas
Nov 24, 1999·Journal of the International Neuropsychological Society : JINS·K K Zakzanis, R W Heinrichs
Dec 11, 1999·Archives of General Psychiatry·S HeckersS L Rauch
Jan 5, 2000·The American Journal of Psychiatry·I C WrightE T Bullmore
May 29, 2000·Journal of the International Neuropsychological Society : JINS·R P KesselsE L van Luijtelaar
Oct 3, 2000·Development and Psychopathology·S Marenco, D R Weinberger

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Citations

Jul 3, 2008·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Aug 16, 2005·Current Psychiatry Reports·Laurie M McCormick, Michael Flaum
Jan 7, 2006·Epidemiologia e psichiatria sociale·Assen Jablensky
Oct 27, 2006·Journal of the International Neuropsychological Society : JINS·Stephanie McDermid Vaz, R Walter Heinrichs
Mar 31, 2005·The American Psychologist·R Walter Heinrichs
Oct 20, 2006·Journal of Clinical and Experimental Neuropsychology·Paul J MobergBruce I Turetsky
Apr 21, 2009·Schizophrenia Bulletin·Raymond C K ChanYa Wang
Jan 10, 2013·Annual Review of Clinical Psychology·Gregory A Miller, Brigitte Rockstroh
Feb 9, 2016·Psychophysiology·Thomas KustermannTzvetan Popov
Jul 31, 2012·Schizophrenia Research·Zachary D MoranCindy M Yee
Jun 15, 2011·Progress in Neurobiology·Viola Oertel-KnöchelHarald Hampel
Nov 26, 2010·Biological Psychiatry·Tzvetan PopovGregory A Miller
Jul 22, 2010·Schizophrenia Research·Narmeen AmmariAshley A Miles
Sep 29, 2009·Schizophrenia Research·Yoji HiranoToshiaki Onitsuka
Oct 11, 2008·Brain and Cognition·Gillian A O'Driscoll, Brandy L Callahan
Jul 4, 2008·L'Encéphale·L HolzerL Jaugey
Feb 23, 2008·Schizophrenia Research·Rajiv TandonHenry A Nasrallah
Sep 15, 2007·Neuroscience and Biobehavioral Reviews·Szabolcs Kéri
Apr 7, 2007·Psychiatry Research·Robert J ThomaJose M Cañive
Jul 31, 2008·Psychophysiology·J Christopher EdgarGregory A Miller
Oct 10, 2013·Psychiatry and Clinical Neurosciences·Toshiaki OnitsukaShigenobu Kanba
Sep 29, 2011·Psychophysiology·Anna DaleckiStuart J Johnstone
Mar 8, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Stephen M LawrieAndrew M McIntosh
Sep 29, 2006·Schizophrenia Research·Jeffrey S BedwellElizabeth Baksh
Jun 18, 2015·NeuroImage. Clinical·Tzvetan G PopovBrigitte S Rockstroh
Aug 4, 2010·Neuroscience·L DuffyT Karl
Apr 29, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Anna DaleckiRodney J Croft
Jun 17, 2014·Schizophrenia Research·Almut M CarolusBrigitte S Rockstroh
Feb 13, 2007·NeuroImage·Oleg KorzyukovNashaat N Boutros
Jul 5, 2007·The International Journal of Neuropsychopharmacology·Jonathan B SavitzRajkumar S Ramesar
Sep 20, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Andre F MarquandChristian F Beckmann
Sep 14, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Peter E Clayson, Gregory A Miller

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