Meta-analysis for rare events.

Statistics in Medicine
Tianxi CaiLouise Ryan

Abstract

Meta-analysis provides a useful framework for combining information across related studies and has been widely utilized to combine data from clinical studies in order to evaluate treatment efficacy. More recently, meta-analysis has also been used to assess drug safety. However, because adverse events are typically rare, standard methods may not work well in this setting. Most popular methods use fixed or random effects models to combine effect estimates obtained separately for each individual study. In the context of very rare outcomes, effect estimates from individual studies may be unstable or even undefined. We propose alternative approaches based on Poisson random effects models to make inference about the relative risk between two treatment groups. Simulation studies show that the proposed methods perform well when the underlying event rates are low. The methods are illustrated using data from a recent meta-analysis (N. Engl. J. Med. 2007; 356(24):2457-2471) of 48 comparative trials involving rosiglitazone, a type 2 diabetes drug, with respect to its possible cardiovascular toxicity.

Citations

Aug 23, 2012·Journal of the National Cancer Institute·Lucas Vieira dos SantosJoão Paulo da Silveira Nogueira Lima
Aug 13, 2015·Ecological Applications : a Publication of the Ecological Society of America·Summer L MartinJeffrey E Moore
Mar 1, 2012·Research Synthesis Methods·Jonathan J ShusterJay S Skyler
Feb 4, 2012·Statistics in Medicine·Pantelis G Bagos
Jun 26, 2013·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ahmed ElkhademDerek Richards
Apr 9, 2014·Statistics in Medicine·E MorenoM A Negrín
Mar 7, 2014·Statistics in Medicine·Bernhard Klingenberg
Apr 30, 2016·Statistics in Biopharmaceutical Research·Ou BaiXinlei Wang
Apr 29, 2015·Biometrical Journal. Biometrische Zeitschrift·Dankmar BöhningAlan Kimber
Jan 27, 2015·Journal of the American Statistical Association·Dungang LiuMinge Xie
Jan 18, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Carlo MengoliGiancarlo Maria Liumbruno
Apr 22, 2017·The British Journal of Psychiatry : the Journal of Mental Science·Natalie B V RibletBradley V Watts
Jan 6, 2012·Statistical Methods in Medical Research·Peter W Lane
Oct 21, 2017·Journal of Biopharmaceutical Statistics·Yuanyuan TangShihua Wen
Aug 2, 2017·Statistical Methods in Medical Research·Lie Li, Xinlei Wang
Apr 14, 2018·Evidence-based Mental Health·Orestis Efthimiou
Jun 20, 2018·The Journal of Bone and Joint Surgery. American Volume·James R BerstockAshley W Blom
Dec 14, 2017·Statistical Methods in Medical Research·Orestis EfthimiouGeorgia Salanti
Oct 4, 2018·The New England Journal of Medicine·Jeremy D KeenanUNKNOWN MORDOR Study Group
Jul 28, 2019·Research Synthesis Methods·Burak Kürsad GünhanTim Friede
Feb 18, 2020·Biostatistics·Dankmar Böhning, Patarawan Sangnawakij
Jan 26, 2018·BMJ Evidence-based Medicine·Igho J Onakpoya
May 1, 2020·BMC Medical Research Methodology·Tao JiangGuogen Shan
Apr 29, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andreia AlbuquerqueGary M Clifford
Jun 5, 2020·JAMA Oncology·Andrea ArfèLorenzo Trippa
Jun 9, 2020·Biometrical Journal. Biometrische Zeitschrift·Marie BeisemannHeinz Holling
Oct 5, 2018·The New England Journal of Medicine·Stephen Obaro
Nov 20, 2016·Statistics in Medicine·Björn Holzhauer
Aug 9, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Daniel CaldeiraJoão Costa
Jan 1, 2014·Therapeutic Innovation & Regulatory Science·H Amy Xia, Qi Jiang
Dec 2, 2020·Clinical Trials : Journal of the Society for Clinical Trials·Hwanhee HongGary L Rosner
Mar 30, 2021·PLoS Neglected Tropical Diseases·Sauman Singh-PhulgendaPhilippe J Guerin
Apr 4, 2021·International Journal of Environmental Research and Public Health·Fahad M Al AmerLifeng Lin
Jun 19, 2021·Statistical Methods in Medical Research·Alexander Hodkinson, Evangelos Kontopantelis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.