PMID: 15381515Sep 24, 2004Paper

Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus

Annals of Internal Medicine
Elizabeth SelvinSherita Hill Golden

Abstract

In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear. To conduct a meta-analysis of observational studies of the association between glycosylated hemoglobin and cardiovascular disease in diabetic persons. Search of the MEDLINE database by using Medical Subject Heading search terms and key words related to glycosylated hemoglobin, diabetes, and cardiovascular disease. Prospective cohort studies with data on glycosylated hemoglobin levels and incident cardiovascular disease. Relative risk estimates were derived or abstracted from each cohort study that met the inclusion criteria. Adjusted relative risk estimates for glycosylated hemoglobin (total glycosylated hemoglobin, hemoglobin A1, or hemoglobin A1c levels) and cardiovascular disease events (coronary heart disease and stroke) were pooled by using random-effects models. Three studies involved persons with type 1 diabetes (n = 1688), and 10 studies involved persons with type 2 diabetes (n = 7435). The pooled relative risk for cardiovascular disease was 1.18; this represented a 1-percentage point in...Continue Reading

Associated Clinical Trials

Citations

Oct 29, 2008·Archives of Internal Medicine·Elizabeth SelvinFrederick L Brancati
Nov 26, 2010·JAMA : the Journal of the American Medical Association·Timothy S ChurchConrad P Earnest
Dec 16, 2006·Current Atherosclerosis Reports·Jennifer G Robinson
Aug 6, 2009·Diabetologia·UNKNOWN Control GroupM Woodward
Dec 6, 2007·Journal of General Internal Medicine·Pramod MeduruUsha Sambamoorthi
Jun 10, 2010·Journal of General Internal Medicine·Cheryl P LynchLeonard E Egede
Jan 27, 2007·Current Diabetes Reports·R Jan-Willem Middelbeek, Edward S Horton
Feb 5, 2009·Current Diabetes Reports·Stuart W Zarich
Jun 6, 2009·Current Diabetes Reports·Suma DronovalliGeorge L Bakris
Oct 2, 2009·Current Diabetes Reports·Edoardo Mannucci, Matteo Monami
Apr 29, 2010·Current Diabetes Reports·Stuart W Zarich
Apr 29, 2010·Current Diabetes Reports·Ayotunde O Dokun
Nov 13, 2012·Current Heart Failure Reports·Nael HawwaW H Wilson Tang
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Todd R MarcyDon Harrison
Aug 7, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Lesley J Scott
Oct 18, 2005·The American Journal of Medicine·John E Gerich
Nov 30, 2010·Journal of the American Dietetic Association·Marion J FranzErica Gradwell
Aug 18, 2009·Lancet·John S Yudkin, Bernd Richter
Sep 18, 2012·International Journal of Technology Assessment in Health Care·Doug CoyleRonald J Sigal
Aug 1, 2008·International Journal of Impotence Research·S A M KhatanaW-C Wu
Aug 21, 2009·International Journal of Impotence Research·B G Schwartz, R A Kloner
Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Kay-Tee Khaw
Nov 25, 2005·International Journal of Impotence Research·R ShiriK Falah Hassani
Aug 3, 2005·Journal of Human Hypertension·A PatelN Poulter
Sep 24, 2013·Molecular BioSystems·Sompop BencharitJohn B Buse
Dec 1, 2009·Seminars in Interventional Radiology·Adam Ryan Geronemus, Constantino S Peña
Dec 24, 2005·The New England Journal of Medicine·William T Cefalu
Jun 10, 2008·The New England Journal of Medicine·William T Cefalu

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