Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia.

American Journal of Infection Control
Jia LiGehong Dong

Abstract

We aimed to investigate the relationship between clinical characteristics, outcomes and the severity of severe acute respiratory syndrome coronavirus 2 pneumonia. We performed a systematic review and meta-analysis using PubMed, Embase, and Cochrane Library databases to assess the clinical characteristics and outcomes of confirmed COVID-19 cases and compared severe (ICU) and nonsevere (non-ICU) groups. We included 12 cohort studies including 2,445 patients with COVID-19. Compared with nonsevere (non-ICU) patients, severe (ICU) disease was associated with a smoking history (P = .003) and comorbidities including chronic obstructive pulmonary disease (OR = 5.08, P < .001), diabetes (OR = 3.17, P < .001), hypertension (OR = 2.40, P < .001), coronary heart disease (OR = 2.66, P < .001), cerebrovascular diseases (OR = 2.68, P = .008), and malignancy (OR=2.21, P = .040). We found significant differences between the 2 groups for fever, dyspnea, decreased lymphocyte and platelet counts, and increased leukocyte count, C-creative protein, procalcitonin, lactose dehydrogenase, aspartate aminotransferase, alanine aminotransferase, creatinine kinase, and creatinine levels (P < .05). Significant differences were also observed for multiple trea...Continue Reading

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Citations

Jul 17, 2020·International Journal of Environmental Research and Public Health·Ramy Abou GhaydaJae Il Shin
Sep 6, 2020·Military Medical Research·Ying-Hui JinUNKNOWN Chinese Research Hospital Association (CRHA)
Jan 16, 2021·F1000Research·Mudatsir MudatsirHarapan Harapan
Apr 8, 2021·Journal of Nephrology·Hugo De CarvalhoLucile Figueres
Aug 10, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Sermin BorekciBilun Gemicioglu
Aug 17, 2021·Frontiers in Nutrition·Christine N El Khoury, Sofi G Julien

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